Mohawk is a novel homeobox gene expressed in the developing mouse embryo
Mohawk is a novel homeobox gene expressed in the developing mouse embryo
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DOI：
10.1002/dvdy.20671
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Rawls, A
中科院分区：
文献类型：
--
作者：
Anderson, DM;Arredondo, J;Rawls, A
含有同源结构域的蛋白质包括转录因子的超家族，其参与胚胎发育的几乎所有方面的调节。在这里，我们描述了小鼠胚胎表达模式的莫霍克，一个新的成员的TALE超类的非典型同源异型盒基因是最密切相关的易洛魁类。在小鼠发育过程中，莫霍克在体节衍生的细胞谱系中转录。早在胚胎第9.0天，Mohawk在通常产生骨骼肌的体节的皮肌节的背内侧和腹外侧唇中以前后梯度表达。背内侧区的莫霍克转录需要转录因子旁轴的表达。随着体节的成熟，在肌腱特异性syndetome和硬节衍生的冷凝间充质中观察到Mohawk转录，这些间充质预示着近端肋骨和椎体。在四肢中，莫霍克表达的模式与沿着趾骨的背侧和腹侧形成的肌腱一致。最后，在后肾的输尿管芽和雄性性腺的睾丸索的尖端可以检测到莫霍克。总之，这些观察结果表明，莫霍克是脊椎动物发育的重要调节器。
Homeodomain-containing proteins comprise a superfamily of transcription factors that participate in the regulation of almost all aspects of embryonic development. Here, we describe the mouse embryonic expression pattern of Mohawk, a new member of the TALE superclass of atypical homeobox genes that is most-closely related to the Iroquois class. During mouse development, Mohawk was transcribed in cell lineages derived from the somites. As early as embryonic day 9.0, Mohawk was expressed in an anterior to posterior gradient in the dorsomedial and ventrolateral lips of the dermomyotome of the somites that normally give rise to skeletal muscle. Mohawk transcription in the dorsomedial region required the expression of the transcription factor paraxis. As somites matured, Mohawk transcription was observed in the tendon-specific syndetome and the sclerotome-derived condensing mesenchyme that prefigures the proximal ribs and vertebral bodies. In the limbs, Mohawk was expressed in a pattern consistent with the developing tendons that form along the dorsal and ventral aspect of the phalanges. Finally, Mohawk was detectable in the tips of the ureteric buds in the metanephric kidneys and the testis cords of the male gonad. Together, these observations suggest that Mohawk is an important regulator of vertebrate development.