Brain and arterial abnormalities following prenatal X-ray irradiation in mice assessed by magnetic resonance imaging and angiography
Brain and arterial abnormalities following prenatal X-ray irradiation in mice assessed by magnetic resonance imaging and angiography
复制标题
通过磁共振成像和血管造影评估小鼠产前 X 射线照射后的大脑和动脉异常
DOI：
10.1111/cga.12101
复制
发表时间：
2015
影响因子：
1.3
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Saito;S.;Sawada;K.;Mori;Y.;Yoshioka;Y. and Murase;K.
本研究旨在定量描述产前电离辐射对全脑和动脉形态的影响。使用磁共振成像（MRI）和血管造影（MRA）评价8周龄雄性小鼠在胚胎（E）第13天产前暴露于0.5或1.0戈伊剂量的X射线辐射的脑和动脉异常。辐照小鼠表现出脑体积减少，脑室体积增加，动脉畸形。此外，辐射暴露小鼠大脑前动脉、大脑中动脉和基底动脉的MRA信号强度和动脉厚度低于对照小鼠。MRI和MRA是评估产前辐射暴露后大脑和动脉异常的有用工具。
The present study aimed to quantitatively characterize changes in the whole brain and arterial morphology in response to prenatal ionizing irradiation. Magnetic resonance imaging (MRI) and angiography (MRA) were used to evaluate brain and arterial abnormalities in 8‐week‐old male mice prenatally exposed to X‐ray radiation at a dose of 0.5 or 1.0 Gy on embryonic day (E) 13. Irradiated mice demonstrated decreased brain volume, increased ventricular volume, and arterial malformation. Additionally, MRA signal intensity and arterial thickness in the anterior cerebral artery, middle cerebral artery, and basilar artery were lower in radiation‐exposed mice than in control mice. MRI and MRA are useful tools for assessing brain and arterial abnormalities after prenatal exposure to radiation.