Mechanisms of three-dimensional transcriptional regulation in cell senescence
Mechanisms of three-dimensional transcriptional regulation in cell senescence
复制标题
细胞衰老的三维转录调控机制
DOI：
10.1360/n052016-00355
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Song X.
中科院分区：
文献类型：
--
作者：
Cao J.;Cheng Q.;Luo Z.;Peng Q.;Wu Y.;Song X.
对基因表达的精确调控是细胞分化、发育和维持正常活动和功能的先决条件。许多研究表明，基因转录的激活或抑制不仅受组蛋白修饰、DNA甲基化和其他表观遗传修饰的影响，而且高度依赖于染色质的构象。此外，在细胞衰老过程中，长非编码RNA(LncRNAs)在基因转录调控中也发挥着重要作用。在这里，我们重点介绍最近关于lncRNAs在细胞衰老中作用机制的研究。特别是，我们重点研究了参与染色质三维构象形成的lncRNAs介导的基因转录调控。
Precise regulation of gene expression is a prerequisite for cell differentiation, development, and maintenance of normal activity and function. Many studies have shown that activation or inhibition of gene transcription is not only affected by histone modifications, DNA methylation, and other epigenetic modifications but is also highly dependent on chromatin conformation. In addition, in the process of cellular senescence, long noncoding RNAs (lncRNAs) also play a significant role in gene transcriptional regulation. Here, we highlight recent studies of the mechanism of function of lncRNAs in cellular senescence. In particular, we focus on gene transcription regulation mediated by lncRNAs participating in the formation of the three-dimensional conformation of chromatin.