Perirhinal damage produces modality-dependent deficits in fear learning
Perirhinal damage produces modality-dependent deficits in fear learning
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DOI：
10.1016/j.nlm.2021.107427
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发表时间：
2021-04-09
影响因子：
2.7
通讯作者：
Furtak, Sharon C.
中科院分区：
文献类型：
--
作者：
Bartley, Trevor D.;Furtak, Sharon C.
嗅周皮质(PER)接收来自所有通道的多通道和单通道感觉信息。此外，PER在解剖学上与支持恐惧学习的几个大脑区域有关。一些研究表明，PER参与了对不连续的听觉线索的恐惧条件反射，而不是对连续的听觉线索的恐惧条件反射。到目前为止，研究PER在恐惧条件反射中的作用的研究主要集中在听觉和背景刺激上。本研究评估了PER在恐惧条件反射中的作用是否会扩展到视觉形式。啮齿动物被随机分配到四种条件刺激中的一种，其中包括连续或不连续的音调或光刺激。训练前对PER的兴奋性损伤显着减少了在获取阶段对听觉和视觉线索的冻结，而不考虑刺激的连续性。在随后的测试中，无论是连续音调还是不连续音调，虹膜周围病变都显著降低了冰冻程度，但对两个轻度CS组都没有影响。这些结果表明，PER参与了多种线索形式的恐惧习得。然而，根据线索通道的不同，PER在提取恐惧记忆中的作用可能更为有限。
The perirhinal cortex (PER) receives multimodal and unimodal sensory information from all modalities. In addition, the PER is anatomically connected with several brain regions that support fear learning. Several studies suggest that the PER is involved in fear conditioning to discontinuous auditory cues but not to continuous auditory cues. To date, studies examining the role of the PER in fear conditioning has largely focused on auditory and contextual stimuli. The present study assessed whether the role of the PER in fear conditioning would extend to visual modalities. Rodents were randomly assigned to one of four conditioned stimuli, which consisted of either a tone or a light stimulus that was either continuous or discontinuous. Pre-training excitotoxic lesions to the PER significantly reduced freezing to auditory and visual cues during the acquisition phase regardless of stimulus continuity. During subsequent testing, perirhinal lesions produced significant decreases in freezing levels to both continuous and discontinuous tones but not to either of the light CS groups. These results suggest that the PER is involved in the acquisition of fear across multiple cue modalities. However, the PER may have a more limited role in the retrieval of the fear memory dependent upon the cue modality.