Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations
Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations
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DOI：
10.1177/1179069519872213
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发表时间：
2019-09-12
影响因子：
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通讯作者：
Hinds, Sidney R., II
中科院分区：
文献类型：
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作者：
Bryden, Daniel W.;Tilghman, Jessica I.;Hinds, Sidney R., II
创伤性脑损伤（TBI）是参与军事战斗或碰撞运动等活动的众所周知的后果。但是，在引发环境和损伤严重程度的广泛变化使得TBI作为一个统一的疾病状态的研究是不可能的。军事服务人员受到额外的、独特的威胁，如暴露在爆炸物中及其对身体的独特影响。这篇评论的目的是TBI研究人员，因为它涵盖了重要的概念和考虑，研究爆炸引起的头部创伤。这些问题包括爆炸引起的头部创伤与其他创伤性脑损伤机制的可比性，爆炸超压是否引起可测量的生物标志物，以及生物剂量计是否可以将爆炸暴露与健康结果联系起来，使用急性辐射暴露作为推论。这种检查是上下文的理解，在过去的世纪的战争，以及预测持续TBI和那些沉淀或加剧心理状况的变量的震荡事件和他们的心理影响。
Traumatic brain injury (TBI) is a well-known consequence of participation in activities such as military combat or collision sports. But the wide variability in eliciting circumstances and injury severities makes the study of TBI as a uniform disease state impossible. Military Service members are under additional, unique threats such as exposure to explosive blast and its unique effects on the body. This review is aimed toward TBI researchers, as it covers important concepts and considerations for studying blast-induced head trauma. These include the comparability of blast-induced head trauma to other mechanisms of TBI, whether blast overpressure induces measureable biomarkers, and whether a biodosimeter can link blast exposure to health outcomes, using acute radiation exposure as a corollary. This examination is contextualized by the understanding of concussive events and their psychological effects throughout the past century's wars, as well as the variables that predict sustaining a TBI and those that precipitate or exacerbate psychological conditions.