B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment.
B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment.
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DOI：
10.1182/blood-2002-03-0733
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发表时间：
2002-11
期刊：
影响因子：
20.3
通讯作者：
Y. Hashimoto;E. Montecino-Rodriguez;H. Leathers;R. Stephan;K. Dorshkind
中科院分区：
文献类型：
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作者：
Y. Hashimoto;E. Montecino-Rodriguez;H. Leathers;R. Stephan;K. Dorshkind
B 细胞前体存在于胸腺中，胸腺微环境是包括白细胞介素 7 (IL-7) 在内的淋巴细胞生成因子的来源。尽管胸腺内 B 细胞祖细胞是骨髓来源的细胞，但本报告中的数据表明，这些祖细胞在发育的早期前 B 细胞阶段积累，周期比骨髓对应物少，并且无法有效分化。本文提出的其他研究表明，这些作用至少部分是由胸腺微环境产生的可溶性因子介导的，并表明它们影响 pro-B 细胞对 IL-7 最佳反应的能力。总而言之，这些观察结果证明了胸腺内 B 淋巴细胞生成的特异性抑制，这反过来可以解释为什么胸腺中的淋巴细胞生成很大程度上局限于 T 谱系细胞的生成，尽管该器官中存在 B 细胞前体和 B 淋巴细胞生成刺激。
B-cell precursors are present in the thymus, and the thymic microenvironment is the source of lymphopoietic factors that include interleukin-7 (IL-7). Despite the fact that intrathymic B-cell progenitors are bone marrow-derived cells, the data in this report demonstrate that these progenitors accumulate at an early pro-B-cell stage of development, cycle less than their bone marrow counterparts, and fail to differentiate efficiently. Additional studies presented herein indicate that these effects are mediated, at least in part, by soluble factors produced by the thymic microenvironment and suggest that they affect the ability of pro-B cells to respond optimally to IL-7. Taken together, these observations demonstrate a specific inhibition of intrathymic B lymphopoiesis, which in turn may explain why lymphoid cell production in the thymus is largely restricted to production of T-lineage cells despite the fact that B-cell precursors and B-lymphopoietic stimuli are present in that organ.