Observations on the antibody responses in molluscum contagiosum
Observations on the antibody responses in molluscum contagiosum
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传染性软疣中抗体反应的观察
DOI：
10.1111/j.1365-2133.1977.tb05182.x
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发表时间：
1977
影响因子：
10.3
通讯作者：
R. Matthews
中科院分区：
文献类型：
--
作者：
P. Shirodaria;R. Matthews
对传染性软疣单发或多发病变患者病毒粒子抗原的调查显示，所有病变均含有病毒抗原。在棘细胞层、颗粒层和角蛋白层中检测到病毒粒子抗原。抗牛痘、兔痘和鼠痘的超免疫血清不能染色传染性软疣病变的包涵体。69%的患者存在病毒特异性抗体。虽然病毒特异性IgG抗体占多数，但在少数患者中发现病毒特异性IgM和病毒特异性IgA抗体。在邻近传染性软疣病变的正常皮肤的刺细胞层、颗粒层和角蛋白层观察到IgM染色。治疗后少数患者出现病毒特异性抗体反应。
A survey of the incidence of molluscum contagiosum virion antigens in patients with single or multiple lesions showed that all lesions contain virus antigen. The virion antigens were detected in the prickle cell, granular and keratin layers. Hyperimmune sera against vaccinia, rabbit‐pox and mouse‐pox failed to stain the inclusion bodies in molluscum contagiosum lesions. Virus‐specific antibodies were present in 69% of the patients. Although virus‐specific IgG antibody was predominant, virus‐specific IgM and virus‐specific IgA were found in a few patients. An IgM staining in the prickle cell, granular and keratin layers of normal skin adjoining the molluscum contagiosum lesion was observed. The virusspecific antibody response was induced in a few patients after the treatment.