A bi-directional μ-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat
A bi-directional μ-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat
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DOI：
10.1016/j.brainres.2004.10.001
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发表时间：
2004-12-10
期刊：
影响因子：
2.9
通讯作者：
O'Hare, E
中科院分区：
文献类型：
--
作者：
Kim, EM;Quinn, JG;O'Hare, E
杏仁核中央核 (CeA) 和伏隔核 (NAc) 已被证明参与阿片类药物介导的进食行为。本研究检查了 CeA 和 NAc 之间的 mu-阿片类信号传导是否影响进食。雄性 Sprague-Dawley 大鼠在 CeA 中安装一根插管，在 NAc 中安装两根插管，这样可以在一个部位同时施用 mu-阿片受体激动剂 [D-Ala(2)、NMe-Phe(4)、Gly-ol(5)]-脑啡肽 (DAMGO)，在另一部位共同施用阿片拮抗剂纳曲酮 (NTX)。将 DAMGO (2.4 nmol) 单次注射到 CeA 中，将 DAMGO (2.4 nmol) 双侧注射到 NAc 中刺激进食 (P
The central nucleus of the amygdala (CeA) and the nucleus of the accumbens shell (NAc) have been shown to be involved in opioid-mediated feeding behavior. The present study examined whether mu-opioid signalling between the CeA and NAc affected feeding. Male Sprague-Dawley rats were fitted with one cannula placed in the CeA and two cannulae placed in the NAc, which allowed for coadministration of the mu-opioid receptor agonist [D-Ala(2), NMe-Phe(4), Gly-ol(5)]-enkephalin (DAMGO) in one site and the opioid antagonist naltrexone (NTX) in the other site. Single injection of DAMGO (2.4 nmol) into the CeA and bilateral injections of DAMGO (2.4 nmol) into the NAc stimulated feeding (P