An Overactive Bladder Symptom and Health-Related Quality of Life Short-Form: Validation of the OAB-q SF
An Overactive Bladder Symptom and Health-Related Quality of Life Short-Form: Validation of the OAB-q SF
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DOI：
10.1002/nau.22559
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发表时间：
2015-03-01
影响因子：
2
通讯作者：
Sexton, Chris C.
中科院分区：
文献类型：
--
作者：
Coyne, Karin S.;Thompson, Christine L.;Sexton, Chris C.
目的：膀胱过度活动症问卷（OAB-q）在控制和失禁OAB患者中表现出强大的心理测量特性。然而，对于完成完整的OAB-q可能过于繁重的设置，需要该仪器的简短形式。本手稿的目的是描述OAB-q简表的验证。研究方法：三项研究用于推导和验证OAB-q SF：托特罗定ER的12周、多中心、开放标签临床试验（N = 865例尿失禁OAB [I-OAB];“Noble巢式病例对照”[NCC]研究; N = 523例健康对照; N = 396例OAB）;和一项重测验证研究（N = 47）。采用Rasch分析和验证性因素分析（CFA）对量表的结构进行了分析，并对量表的心理测量学性能进行了评价。结果：根据Rasch分析，OAB-q SF症状困扰量表保留6个条目，HRQL量表保留13个条目。CFA在研究人群中显示出极好的模型拟合和内部一致性。两个量表都表现出良好的收敛效度，判别效度，内部信度，再现性和变化的反应。OAB-q SF量表在I-OAB、C-OAB和健康对照之间存在明显差异。结论：OAB-q SF捕获了OAB症状困扰和HRQL影响的全谱，具有良好的可靠性、有效性和响应性，同时患者完成所需的时间更少。(C)2014 Wiley Periodicals，Inc.
Aims: The Overactive Bladder Questionnaire (OAB-q) has demonstrated robust psychometric properties in continent and incontinent OAB patients. However, there is a need for a short-form of this instrument for settings where completing the full OAB-q may be too burdensome. The purpose of this manuscript is to describe the validation of the OAB-q short-form. Methods: Three studies were used to derive and validate the OAB-q SF: a 12-week, multicenter, open-label clinical trial of tolterodine ER (N = 865 incontinent OAB [I-OAB]; the "Noble Nested Case-Control'' [NCC] study; N = 523 healthy controls; N = 396 OAB); and a test-retest validation study (N = 47). Rasch analysis and confirmatory factor analysis (CFA) were performed to assess the subscale structure, and the psychometric performance of the resulting scales was evaluated. Results: Based on the Rasch analysis, 6-items were retained in the OAB-q SF Symptom Bother Scale and 13-items were retained in the HRQL scale. CFAs showed excellent model fit and internal consistency in the study populations. Both scales demonstrated good convergent validity, discriminant validity, internal reliability, reproducibility, and responsiveness to change. The OAB-q SF scales clearly differentiated among I-OAB, C-OAB, and healthy controls. Conclusion: The OAB-q SF captures the full spectrum of OAB Symptom Bother and HRQL impact with good reliability, validity, and responsiveness, while being less time-consuming for patients to complete. (C) 2014 Wiley Periodicals, Inc.