Sleep-wake patterns of intact and carotid sinus nerve sectioned rats during hypoxia.
Sleep-wake patterns of intact and carotid sinus nerve sectioned rats during hypoxia.
复制标题
缺氧期间完整和颈动脉窦神经切片的大鼠的睡眠-觉醒模式。
DOI：
10.1093/sleep/5.1.1
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发表时间：
1982
期刊：
影响因子：
5.6
通讯作者：
David Megirian
中科院分区：
文献类型：
--
作者：
T. Ryan Ann;David Megirian
6只雄性大鼠在颈动脉窦神经（CSN）切断前后呼吸21和10%O2。多导记录技术用于监测睡眠和觉醒。研究了这些气体混合物对大鼠睡眠-觉醒模式（SWP）的影响。CSN切段大鼠呼吸21%O_2时的SWP与正常大鼠相比无明显变化。当呼吸10%O2时，完整大鼠的SWP显著改变。低氧暴露第一天无旁睡眠（PS）。CSN切片后，SWP接近常氧条件下大鼠的SWP。PS的量显著增加。可以得出结论，外周化学感受器反射通路有助于，部分，在缺氧条件下，但不是在常氧条件下的SWP中断。由于缺氧的意识状态的变化的机制进行了讨论。
Six male rats breathed 21 an 10% O2 before and after carotid sinus nerve (CSN) section. Polygraphic recording techniques were used to monitor sleep and wakefulness. The effects that these gas mixtures had on the rats' sleep-wake pattern (SWP) were studied. The SWP of CSN sectioned rats breathing 21% O2 was unchanged compared with that of intact rats. While breathing 10% O2, the intact rats' SWP was altered dramatically. Paradoxical sleep (PS) was absent on the first day's exposure to hypoxia. After CSN section, the SWP approximated that of rats in normoxic conditions. The amount of PS increased considerably. It is concluded that the peripheral chemoreceptor reflex pathway contributes, in part, to disruption of the SWP under hypoxic conditions, but not under normoxic conditions. Mechanisms underlying changes in states of consciousness due to hypoxia are discussed.