THE RESPONSE TO LONG-TERM OVERFEEDING IN IDENTICAL-TWINS
THE RESPONSE TO LONG-TERM OVERFEEDING IN IDENTICAL-TWINS
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DOI：
10.1056/nejm199005243222101
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发表时间：
1990-05-24
影响因子：
158.5
通讯作者：
FOURNIER, G
中科院分区：
文献类型：
--
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
我们进行了这项研究，以确定是否有不同的人长期过度喂养的反应存在差异，并评估基因型参与这种差异的可能性。在两周的基线期后，12对年轻的成年男性单卵双胞胎每天被过量喂养4.2 MJ（1000千卡），每周6天，在100天的时间内总共84天。每个人消耗的总过量量为353 MJ（84，000千卡）。在过度喂养期间，个体的身体组成和脂肪沉积的地形变化差异很大。平均体重增加为8.1 kg，但范围为4.3 - 13.3 kg。在体重、脂肪百分比、脂肪质量和估计的皮下脂肪方面，每对内对过度喂养的反应的相似性是显著的（P < 0.05），其中对之间的方差比对内的方差大约三倍（r <0.05）。0.5）。在对脂肪量的增加进行调整后，在区域脂肪分布和腹部内脏脂肪量的变化方面，对内的相似性特别明显（P < 0.01），对间的方差约为对内的六倍（r = 0.001）。0.7）。我们得出的结论是，对于适应长期过度喂养的对内相似性以及双胞胎对之间体重增加和脂肪分布的差异，最可能的解释是涉及遗传因素。这些因素可能决定了将能量储存为脂肪或瘦肉组织的倾向，以及静息时能量消耗的各种决定因素。
We undertook this study to determine whether there are differences in the responses of different persons to long-term overfeeding and to assess the possibility that genotypes are involved in such differences. After a two-week base-line period, 12 pairs of young adult male monozygotic twins were overfed by 4.2 MJ (1000 kcal) per day, 6 days a week, for a total of 84 days during a 100-day period. The total excess amount each man consumed was 353 MJ (84,000 kcal). During overfeeding, individual changes in body composition and topography of fat deposition varied considerably. The mean weight gain was 8.1 kg, but the range was 4.3 to 13.3 kg. The similarity within each pair in the response to overfeeding was significant (P < 0.05) with respect to body weight, percentage of fat, fat mass, and estimated subcutaneous fat, with about three times more variance among pairs than within pairs (r .apprxeq. 0.5). After adjustment for the gains in fat mass, the within-pair similarity was particularly evident with respect to the changes in regional fat distribution and amount of abdominal visceral fat (P < 0.01), with about six times as much variance among pairs as within pairs (r .apprxeq. 0.7). We conclude that the most likely explanation for the intrapair similarity in the adaptation to long-term overfeeding and for the variations in weight gain and fat distribution among the pairs of twins in that genetic factors are involved. These may govern the tendency to store energy as either fat or lean tissue and the various determinants of the resting expenditure of energy.