Context-dependent associations of the ACE I/D polymorphism with blood pressure.
Context-dependent associations of the ACE I/D polymorphism with blood pressure.
复制标题
ACE I/D 多态性与血压的背景依赖性关联。
DOI：
10.1161/01.hyp.34.4.773
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Sing,CF
中科院分区：
文献类型：
--
作者：
Turner,ST;Boerwinkle,E;Sing,CF
—本研究的目的是评估性别、年龄或体型测量对血压的影响在编码血管紧张素转换酶（ACE）的基因的插入/缺失（I/D）多态性的基因型之间是否是同质的。我们研究了来自明尼苏达州罗切斯特市普通人群的 1875 名年龄在 5 岁至 90 岁之间的非西班牙裔白人样本（988 名女性和 887 名男性受试者）。当不考虑 I/D 多态性与年龄、身高和体重相关效应之间的统计相互作用时，没有证据表明血压水平或诊断类别（高血压与正常血压）的变化与任一性别的 ACE 基因型变化之间存在显着关系。然而，在5至29.9岁的女性中，收缩压水平与年龄和体重的线性回归关系以及舒张压水平与年龄的线性回归关系在ACE基因型之间存在显着异质性。对于这些伴随性状，与每种基因型相关的预期血压水平的排名顺序从伴随性状的低值（其中I/D杂合子的血压低于II或DD纯合子）到伴随性状的高水平（其中I/D杂合子的血压高于II或DD纯合子）。在50至90岁的男性受试者中，高血压概率与身高的逻辑回归关系在ACE基因型之间也存在异质性；在 II 纯合子中具有统计学显着性，但在 I/D 杂合子或 DD 纯合子中不具有统计学显着性。这项研究的结果与以下结论一致：ACE 基因变异对个体间血压差异的影响取决于以性别、年龄和体型测量为索引的背景。
—The objective of the present study was to assess whether the influences of gender, age, or measures of body size on blood pressure are homogeneous among genotypes of the insertion/deletion (I/D) polymorphism of the gene that codes for angiotensin-converting enzyme (ACE). We studied a sample of 1875 non-Hispanic white individuals (988 female and 887 male subjects) between 5 and 90 years of age from the general population of Rochester, Minn. When statistical interactions between effects associated with the I/D polymorphism and age, height, and weight were not considered, there was no evidence of a significant relationship between variation in blood pressure level or diagnostic category (hypertension versus normotension) and variation in ACE genotype in either gender. However, in females 5 to 29.9 years of age, the linear regression relationships of systolic blood pressure level with age and weight and of diastolic blood pressure level with age were significantly heterogeneous among ACE genotypes. For these concomitant traits, the rank order of expected blood pressure levels associated with each genotype reversed from low values of the concomitant, in which blood pressure was lower for I/D heterozygotes than for II or DD homozygous, to high levels of the concomitant, in which blood pressure was higher for I/D heterozygotes than for II or DD homozygotes. In male subjects 50 to 90 years of age, the logistic regression relationship of the probability of having hypertension with height was also heterogeneous among ACE genotypes; it was statistically significant in II homozygotes but not statistically significant in either I/D heterozygotes or DD homozygotes. Findings of this study are consistent with the conclusion that the influence of variation in the ACE gene on interindividual variation in blood pressure is dependent on contexts that are indexed by gender, age, and measures of body size.