TRANSITORY MACROPHAGES IN THE WHITE MATTER OF THE DEVELOPING VISUAL-CORTEX .2. DEVELOPMENT AND RELATIONS WITH AXONAL PATHWAYS
TRANSITORY MACROPHAGES IN THE WHITE MATTER OF THE DEVELOPING VISUAL-CORTEX .2. DEVELOPMENT AND RELATIONS WITH AXONAL PATHWAYS
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DOI：
10.1016/0165-3806(83)90201-8
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
KOPPEL, H
中科院分区：
文献类型：
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作者：
INNOCENTI, GM;CLARKE, S;KOPPEL, H
猫在出生后第一周结束时，枕骨皮层白质中出现了发光细胞簇。这些群集，以及其他在出生时就已经存在的群集，在出生后第一个月结束时消失。枕部白质簇的寿命与暂时性胼胝体轴突消失的时期相对应。这些团簇与胼胝体轴突密切接触，可以通过对侧半球注射辣根过氧化物酶（HRP）进行标记，并通过胼胝体运输。其中一个簇明显形成于短暂胼胝体轴突交叉的白质部分。发光细胞可能参与了这些轴突的消除。与这一假设一致的是，超微结构观察显示轴突群完全被闪烁的细胞质包围，好像它们被吞噬了一样。
Clusters of gitter cells develop in the white matter of the occipital cortex of the cat at the end of the 1st postnatal week. These clusters, and others already present at birth, disappear by the end of the 1st postnatal month. The life span of the clusters in the occipital white matter corresponds to the period when transitory callosal axons are eliminated. The clusters have close contact with callosal axons and can be labeled by HRP [horseradish peroxidase] injected in the contralateral hemisphere and transported through the corpus callosum. One of the clusters clearly forms in a part of the white matter crossed by transitory callosal axons. The gitter cells might be involved in the elimination of these axons. Consistent with this hypothesis, ultrastructural observations show groups of axons completely surrounded by gitter cell cytoplasm as if they were being phagocytosed.