Mechanical responses of the rat uterus, cervix, and bladder to stimulation of hypogastric and pelvic nerves in vivo.
Mechanical responses of the rat uterus, cervix, and bladder to stimulation of hypogastric and pelvic nerves in vivo.
复制标题
大鼠子宫、子宫颈和膀胱对体内腹下神经和盆腔神经刺激的机械反应。
DOI：
10.1095/biolreprod40.2.209
复制
发表时间：
1989
影响因子：
3.6
通讯作者：
Robert E. Garfield
中科院分区：
文献类型：
--
作者：
S. Sato;R. Hayashi;Robert E. Garfield
在电刺激腹下神经或盆腔神经的过程中，在麻醉大鼠体内记录子宫、子宫颈和膀胱的机械活动。使用卵巢切除对照组和去势治疗组以及妊娠和产后大鼠。无论是腹下或骨盆神经刺激产生电压和频率依赖性收缩的三个器官没有明显的抑制证据。河豚毒素可完全消除上述诱发反应，提示这些神经是支配上述三个器官的共同通路。阿托品消除子宫和宫颈的反应，腹下和盆腔神经刺激，而膀胱的反应只有部分减少。六烃季铵几乎完全阻断子宫和宫颈的诱发反应。酚妥拉明部分阻断子宫和宫颈的反应，普萘洛尔或毒扁豆碱增强子宫和宫颈对腹下神经和盆腔神经刺激的反应。这些结果表明，运动神经支配的大鼠子宫和子宫颈主要是节后胆碱能，与一些α和β-肾上腺素能成分，膀胱主要是胆碱能神经和非胆碱能神经支配。雌激素和雌孕激素预处理显著增加子宫和宫颈的反应，但不膀胱。子宫和宫颈对腹下神经或盆腔神经刺激的反应在妊娠后期明显降低，并在分娩后7天内再次出现。
Mechanical activities of the uterus, cervix, and bladder were recorded in vivo in anesthetized rats during electrical stimulation of either the hypogastric or pelvic nerve. Ovariectomized controls and hormone-treated groups were used as well as pregnant and postpartum rats. Stimulation of either hypogastric or pelvic nerve produced voltage- and frequency-dependent contractions of the three organs with no evidence of apparent inhibition. All evoked responses were completely abolished by tetrodotoxin, suggesting that these nerves are common pathways of innervation to the three organs. Atropine abolished uterine and cervical responses to both hypogastric and pelvic nerve stimulation, whereas bladder responses were only partly reduced. Hexamethonium almost totally blocked the evoked responses of the uterus and cervix. Phentolamine partly blocked uterine and cervical responses, and propranolol or physostigmine enhanced uterine and cervical responses to both hypogastric and pelvic nerve stimulation. These results suggest that motor innervation to the rat uterus and cervix is predominantly postganglionic cholinergic, with some alpha- and beta-adrenergic components, and that the bladder is innervated by mainly cholinergic and also noncholinergic nerves. Estrogen and estrogen-plus-progesterone pretreatment significantly increased the responses of uterus and cervix but not bladder. Uterine and cervical responses to either hypogastric or pelvic nerve stimulation were markedly reduced late in pregnancy and reappeared within 7 days after delivery.