Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites
Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites
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DOI：
10.1038/sj.leu.2403501
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发表时间：
2004-10-01
期刊：
影响因子：
11.4
通讯作者：
Chott, A
中科院分区：
文献类型：
--
作者：
Streubel, B;Simonitsch-Klupp, I;Chott, A
尽管已知 MALT 淋巴瘤中会出现几种复发性遗传畸变，但目前还没有针对最常见的 MALT 淋巴瘤相关遗传畸变的全面研究。因此，我们筛查了 252 例原发性 MALT 淋巴瘤的易位 t(11; 18)(q21; q21)、t( 14; 18) (q32; q21) 和 t(1; 14)(p22; q32) 以及三体性 3 和 18。上述易位相互排斥发生，总体在 13.5、 10.8%，1.6%； 3 号和/或 18 三体的发生率为 42.1%。易位发生的频率随疾病的原发部位而显着变化。 t(11;18)(q21;q21)主要见于肺肿瘤和胃肿瘤，而t(14;18)(q32;q21)最常见于眼附件/眼眶、皮肤和唾液腺病变。 3 号三体和 18 号三体在肠道和唾液腺 MALT 淋巴瘤中最常见。我们的结果表明，在不同部位的 MALT 淋巴瘤中，三种易位以及 3 号和 18 号三体性的发生频率明显不同。
Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11; 18)(q21; q21), t( 14; 18) (q32; q21), and t(1; 14)(p22; q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11; 18)( q21; q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14; 18)(q32; q21) was most commonly found in lesions of the ocular adnexa/ orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.