Superoxide Anions and NO in the Paraventricular Nucleus Modulate the Cardiac Sympathetic Afferent Reflex in Obese Rats.
Superoxide Anions and NO in the Paraventricular Nucleus Modulate the Cardiac Sympathetic Afferent Reflex in Obese Rats.
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室旁核中的超氧阴离子和 NO 调节肥胖大鼠心脏交感传入反射
DOI：
10.3390/ijms19010059
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发表时间：
2017-12-27
影响因子：
5.6
通讯作者：
Zhou YB
中科院分区：
文献类型：
--
作者：
Lu QB;Sun J;Kang Y;Sun HJ;Wang HS;Wang Y;Zhu GQ;Zhou YB
This study was conducted to explore the hypothesis that the endogenous superoxide anions (O2−) and nitric oxide (NO) system of the paraventricular nucleus (PVN) regulates the cardiac sympathetic afferent reflex (CSAR) contributing to sympathoexcitation in obese rats induced by a high-fat diet (42% kcal as fat) for 12 weeks. CSAR was evaluated by monitoring the changes of renal sympathetic nerve activity (RSNA) and the mean arterial pressure (MAP) responses to the epicardial application of capsaicin (CAP) in anaesthetized rats. In obese rats with hypertension (OH group) or without hypertension (OB group), the levels of PVN O2−, angiotensinII (Ang II), Ang II type 1 receptor (AT1R), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase were elevated, whereas neural NO synthase (nNOS) and NO were significantly reduced. Moreover, CSAR was markedly enhanced, which promoted the elevation of plasma norepinephrine levels. The enhanced CSAR was attenuated by PVN application of the superoxide scavenger polyethylene glycol-superoxide dismutase (PEG-SOD) and the NO donor sodium nitroprusside (SNP), and was strengthened by the superoxide dismutase inhibitor diethyldithiocarbamic acid (DETC) and the nNOS inhibitor N(ω)-propyl-l-arginine hydrochloride (PLA); conversely, there was a smaller CSAR response to PLA or SNP in rats that received a low-fat (12% kcal) diet. Furthermore, PVN pretreatment with the AT1R antagonist losartan or with PEG-SOD, but not SNP, abolished Ang II-induced CSAR enhancement. These findings suggest that obesity alters the PVN O2− and NO system that modulates CSAR and promotes sympathoexcitation.
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影响因子：
3.7
作者：
Gan XB;Sun HJ;Chen D;Zhang LL;Zhou H;Chen LY;Zhou YB
通讯作者：
Zhou YB
影响因子：
2.7
作者：
Rossi NF;Maliszewska-Scislo M;Chen H;Black SM;Sharma S;Ravikov R;Augustyniak RA
通讯作者：
Augustyniak RA
影响因子：
4
作者：
Martins-Pinge MC;Mueller PJ;Foley CM;Heesch CM;Hasser EM
通讯作者：
Hasser EM
室旁核中的活性氧介导慢性心力衰竭大鼠的心脏交感传入反射
影响因子：
18.2
作者：
Han, Ying;Shi, Zhen;Zhu, Guo-Qing
通讯作者：
Zhu, Guo-Qing
DOI：
10.1152/ajprenal.00537.2014
发表时间：
2015-01-15
影响因子：
4.2
作者：
Mittwede, Peter N.;Xiang, Lusha;Hester, Robert L.
通讯作者：
Hester, Robert L.