PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT
PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT
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DOI：
10.1002/ana.410300410
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发表时间：
1991-10-01
影响因子：
11.2
通讯作者：
KATZMAN, R
中科院分区：
文献类型：
--
作者：
TERRY, RD;MASLIAH, E;KATZMAN, R
我们在此提出了线性回归和多变量分析，将三项全球神经心理学测试与一系列结构和神经化学测量相关联，这些测试对15名阿尔茨海默病患者和9名神经病理正常的受试者进行了前瞻性系列研究。统计数据显示，心理测量指标与斑块和神经缠结之间只有微弱的相关性，但通过一种新的免疫细胞化学/密度测量技术测量的新皮层突触密度显示，与所有三种心理分析之间存在非常强的相关性。通过逐步回归的多变量分析，得出Mattis's痴呆评定量表的模型包括额中下顶叶突触密度和下顶叶斑块数量，相关系数为0.96。斑块密度仅占强度的26%。
We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of 15 patients with Alzheimer's disease and 9 neuropathologically normal subjects. The statistical data show only weak correlations between psychometric indices and plaques and tangles, but the density of neocortical synapses measured by a new immunocytochemical/densitometric technique reveals very powerful correlations with all three psychological assays. Multivariate analysis by stepwise regression produced a model including midfrontal and inferior parietal synapse density, plus inferior parietal plaque counts with a correlation coefficient of 0.96 for Mattis's Dementia Rating Scale. Plaque density contributed only 26% of that strength.