An investigation into the health-related quality of life of individuals living with HIV who are receiving HAART
An investigation into the health-related quality of life of individuals living with HIV who are receiving HAART
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DOI：
10.1080/09540120412331319714
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发表时间：
2005-07-01
影响因子：
1.7
通讯作者：
Darder, M
中科院分区：
文献类型：
--
作者：
Jelsma, J;Maclean, E;Darder, M
卫生当局最近同意向南非艾滋病患者例行提供高效抗逆转录病毒疗法。有必要调查高效抗逆转录病毒疗法对资源匮乏环境中艾滋病毒/艾滋病感染者（PLWHA）健康相关生活质量的影响，因为这将对依从性和治疗结果产生影响。本研究的目的是探讨HAART是否能有效改善生活在资源匮乏社区的WHO第3和第4阶段PWLA患者的自我报告的健康相关生活质量（HRQoL）。一个准实验，前瞻性重复测量设计被用来监测HRQoL随着时间的推移招募到现有的HAART计划的参与者。通过使用Xhosa版EQ-5D确定117名参与者的HRQoL，并在基线、1个月、6个月和12个月进行测量。在12个月的问卷调查时，95名参与者已经接受了12个月的HAART治疗。并非所有参与者都参加了所有后续访问，但只有两名参与者在两三个月后退出了HAART方案。基线时，EQ-5D所有领域中报告的问题的排序均显著高于12个月时。健康状况总体评分的平均得分显著增加（p
The health authorities have recently accepted the routine provision of highly active antiretroviral therapy to persons living with AIDS in South Africa. There is a need to investigate the impact of HAART on the health-related quality of life of people living with HIV/AIDS (PLWHA) in a resource-poor environment, as this will have an influence on compliance and treatment outcome. The aim of this study was to explore whether HAART is efficacious in improving the self-reported health-related quality of life (HRQoL) in a group of PWLA in WHO Stages 3 and 4 living in a resource-poor community. A quasi-experimental, prospective repeated measures design was used to monitor the HRQoL over time in participants recruited to an existing HAART programme. The HRQoL of 117 participants was determined through the use of the Xhosa version of the EQ-5D and measurements were taken at baseline, one, six and 12 months. At the time of the 12-month questionnaire, 95 participants had been on HAART for 12 months. Not all participants attended all follow-up visits, but only two participants had withdrawn from the HAART programme, after two or three months. At baseline, the rank order of problems reported in all domains of the EQ-5D was significantly greater than at 12 months. The mean score on the global rating of health status increased significantly (p