Therapeutic effect of plasma exchange with the biliary drainage in the treatment of obstructive jaundice.
Therapeutic effect of plasma exchange with the biliary drainage in the treatment of obstructive jaundice.
复制标题
血浆置换联合胆道引流治疗梗阻性黄疸的疗效观察
DOI：
10.1111/j.1525-1594.1988.tb02794.x
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发表时间：
1988
影响因子：
2.4
通讯作者：
Yoichi Saitoh
中科院分区：
文献类型：
--
作者：
Harumasa Ohyanagi;Makoto Usami;Hiroki Kimata;Yoichi Saitoh
在梗阻性黄疸动物模型上评价血浆置换联合胆道引流的治疗效果。用新鲜冰冻血浆对胆管结扎、切除后的犬黄疸模型进行血浆置换，同时进行胆道引流。PE和BD后进行常规生化分析。并与单纯BD组进行比较。血浆胆红素水平在PE后突然下降并维持在较低水平，而单纯引流组的胆红素水平逐渐下降。PE组血浆线粒体GOT水平降低提示梗阻性黄疸肝细胞损伤改善。在黄疸大鼠PE沿着BD后2天行肝部分切除术，检测肝组织线粒体功能。肝切除术后，PE组线粒体呼吸控制率和ADP/O比值明显改善。结果表明，在BD治疗的基础上，单次PE治疗可改善肝功能储备。提示PE能缩短胆道恶性梗阻性病变治疗后的黄疸时间，并有改善肝功能的作用。
The effect of therapeutic plasmapheresis combined with biliary drainage was evaluated in obstructive jaundice animal models. Plasma exchange (PE) using fresh-frozen plasma was carried out with biliary drainage (BD) on a canine jaundice model created by the ligation and resection of bile duct. Routine biochemical analyses were done following PE and BD. The result was compared with that of a BD only group. Plasma bilirubin level abruptly dropped after PE and was kept at a lower level, whereas the bilirubin level of the drainage alone group decreased gradually. Decreased plasma mitochondrial GOT level in the PE group suggests improvement of liver cell damage in obstructive jaundice. Mitochondrial function of liver tissue was evaluated following partial hepatectomy, which was carried out 2 days after PE along with BD in jaundice rat. Mitochondrial respiratory control ratio and ADP/O ratio following hepatectomy were improved in the PE group. The results suggest the improvement of hepatic functional reservoir by a single PE treatment in addition to BD treatment. These results show that PE can shorten the icteric period and may improve the hepatic functions after the treatment of malignant obstructive lesion in the biliary tract.