INHIBITION OF N-NITROSOBENZYLMETHYLAMINE-INDUCED ESOPHAGEAL TUMORIGENESIS IN RATS BY ELLAGIC ACID
INHIBITION OF N-NITROSOBENZYLMETHYLAMINE-INDUCED ESOPHAGEAL TUMORIGENESIS IN RATS BY ELLAGIC ACID
复制标题
DOI：
10.1093/carcin/11.1.55
复制
发表时间：
1990-01-01
期刊：
影响因子：
4.7
通讯作者：
STONER, GD
中科院分区：
文献类型：
--
作者：
MANDAL, S;STONER, GD
在这份报告中，我们描述了鞣花酸（EA），在一些水果和坚果中存在的酚类化合物，抑制N-亚硝基苄基甲胺（NBMA）在大鼠食管肿瘤发生的能力。当以0.4和4 g/kg的浓度在半纯化饮食中给药时，EA在生物测定的20周和27周后使NBMA诱导的食管肿瘤的平均数量显著减少（21-55%）。电针对癌前病变和癌性病变均有抑制作用。在溶剂对照组大鼠或仅接受EA的大鼠中未观察到肿瘤。
In this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamine (NBMA) tumorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 g/kg, EA produced a significant (21-55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. EA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone.