Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
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DOI：
10.1023/a:1021615530960
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发表时间：
2002-11-01
影响因子：
4.4
通讯作者：
Boccaccio, GL
中科院分区：
文献类型：
--
作者：
Thomas, MG;Coloma, TAS;Boccaccio, GL
成熟的少突胶质细胞发出许多髓鞘形成过程。过程的生长和扩散需要产生力的分子。我们分析了肌球蛋白 II 轻链激酶抑制剂 ML-7 和 ML-9 在培养的少突胶质细胞中的作用。这两种药物都会影响少突胶质细胞的形状，引起高阶过程的收缩。我们的结果表明，髓鞘形成过程与基质的粘附取决于 MLC 磷酸化，因此可能涉及肌球蛋白 IIA。
Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.