Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area
Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area
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DOI：
10.1152/ajpregu.00226.2007
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Koyama, Yoshimasa
中科院分区：
文献类型：
--
作者：
Salas, Juan Carlos Toledo;Iwasaki, Hiroshi;Koyama, Yoshimasa
背外侧被盖核（LDT）内的胆碱能神经元在快速眼动（REM）睡眠的调节中起着重要作用。由于阴茎勃起发生在REM睡眠期间，因此在未麻醉的头部束缚大鼠中检查了LDT在阴茎勃起中的参与。为了检测阴茎勃起，通过遥测装置测量阴茎海绵体（CSP）压力，同时通过不锈钢丝记录球海绵体（BS）肌肉肌电图。电刺激LDT内及周围可诱发以下三种CSP压力模式：1）完全勃起模式，其特征为CSP压力缓慢增加，伴有与BS肌肉爆发相关的额外的CSP尖峰; 2）肌肉模式，其特征为CSP压力尖峰，但缺乏血管成分，即：1）完全勃起模式。例如，没有基线CSP压力的增加，和3）混合型响应，其特征在于高频CSP压力峰值，随后是完全勃起响应。在LDT内和周围诱发完全勃起，包括更内侧和腹侧。在LDT的前半部分，诱导混合型事件的位点与触发完全勃起的位点混合，而在后半部分，它们是分开的。肌肉反应的部位位于完全勃起部位的外侧。最后，在Barrington核及其周围和中缝背核中诱发了与排尿相同的CSP压力反应。这些结果表明，LDT及其周围区域参与阴茎勃起的调节。此外，中桥脑被盖的不同解剖区域可能在阴茎勃起和排尿的调节中具有特定的作用。
The cholinergic neurons in the laterodorsal tegmental nucleus (LDT) play a crucial role in the regulation of rapid eye movement (REM) sleep. Because penile erection occurs during REM sleep, the involvement of the LDT in penile erection was examined in unanesthetized head-restrained rats. To detect penile erection, corpus spongiosum of the penis (CSP) pressure was measured through a telemetric device with simultaneous bulbospongiosum (BS) muscle EMG recording through stainless wires. Electrical stimulation in and around the LDT induced the following three CSP pressure patterns: 1) a full erection pattern indistinguishable from the nonevoked or spontaneous erection, characterized by a slow increase in CSP pressure with additional sharp CSP peaks associated with BS muscle bursts, 2) a muscular pattern characterized by sharp CSP pressure peaks but in the absence of a vascular component, i. e., without an increase in baseline CSP pressure, and 3) a mixed-type response characterized by high-frequency CSP pressure peaks followed by a full erection response. Full erections were evoked in and around the LDT, including more medially and ventrally. The sites for inducing mixed-type events were intermingled with the sites that triggered full erections in the anterior half of the LDT, whereas they were separated in the posterior half. The sites for muscular responses were lateral to the sites for full erections. Finally, a CSP pressure response identical to micturition was evoked in and around the Barrington's nucleus and in the dorsal raphe nucleus. These results suggest that the LDT and surrounding region are involved in the regulation of penile erection. Moreover, different anatomical areas in the mesopontine tegmentum may have specific roles in the regulation of penile erection and micturition.