Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum
Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum
复制标题
DOI：
10.1097/qad.0b013e3282f560ee
复制
发表时间：
2008-03-30
期刊：
影响因子：
3.8
通讯作者：
Menu, Elisabeth
中科院分区：
文献类型：
--
作者：
Ayouba, Ahidjo;Badaut, Cyril;Menu, Elisabeth
流行病学数据表明，感染疟疾的孕妇母婴传播艾滋病毒-1的风险增加，传播途径不明。我们在这里表明，表面结合的重组恶性疟原虫粘附素硫酸软骨素A蛋白聚糖增加HIV-1复制的人胎盘细胞系BeWo，可能是由恶性疟原虫粘附素诱导的长末端重复驱动的TNF-α刺激。这表明胎盘疟疾可能会增加HIV-1在子宫内传播的风险。
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.