Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels.
Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels.
复制标题
DOI：
10.1016/0959-4388(92)90112-x
复制
发表时间：
1992-06-01
影响因子：
5.7
通讯作者：
Role, L W
中科院分区：
文献类型：
--
作者：
Role, L W
神经元烟碱乙酰胆碱受体是寡聚蛋白复合物，其组成亚基分别由一个同源基因家族编码。目前的挑战是确定相关亚基对它们组成的受体连接离子通道的功能贡献，并揭示体内表达的不同通道类别的生理影响。在过去的一年中，分析这些受体的新方法已经对它们的化学计量学、药理学和功能特性产生了重要的见解。
Neuronal nicotinic acetylcholine receptors are oligomeric protein complexes whose component subunits are each encoded by a family of homologous genes. The current challenge is to determine the functional contributions of the related subunits to the receptor-linked ion channels they compose and to uncover the physiological impact of the distinct channel classes expressed in vivo. In the past year, new approaches to the analysis of these receptors have yielded important insights into their stoichiometry, pharmacology and functional properties.