Household outbreaks among culture-confirmed cases of bacterial gastrointestinal disease
Household outbreaks among culture-confirmed cases of bacterial gastrointestinal disease
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DOI：
10.1093/aje/kwh049
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发表时间：
2004-02-15
影响因子：
5
通讯作者：
Molbak, K
中科院分区：
文献类型：
--
作者：
Ethelberg, S;Olsen, KEP;Molbak, K
为了检查家庭爆发的一般频率，作者在丹麦（一个拥有530万居民的国家）的五种最常见的胃肠道细菌病原体病例中进行了回顾性搜索。这是对1991年至2001年登记的57 667例病例进行的，找到了所有共享地址并在3周内感染的病例。在家庭暴发的病例中，弯曲杆菌占3.2%，沙门氏菌血清型占13.3%，鼠伤寒沙门氏菌血清型占5.6%，小肠结肠炎耶尔森氏菌占2.0%，宋内志贺菌占10.4%。绝大多数疫情以前没有登记。不同类型的细菌引起家庭爆发的能力存在很大差异，这反映了它们的流行病学差异，也很可能反映了它们的总体爆发潜力。家庭成员感染之间的时间差异也可能表明不同类型的细菌在人与人之间传播的重要性方面的差异。家庭暴发发生频率相对较高的事实可用于今后对感染源的分析，特别是弯曲杆菌，因为确定了比预期更多的家庭暴发。
To examine the general frequency of household outbreaks, the authors performed a retrospective search among cases of the five most frequent gastrointestinal bacterial pathogens in Denmark, a country of 5.3 million inhabitants. This was done for 57,667 cases registered from 1991 to 2001 by finding all cases that shared addresses and became infected within 3 weeks of one another. The percentage of cases that were part of household outbreaks was found to be 3.2% for Campylobacter, 13.3% for Salmonella serotype Enteritidis, 5.6% for Salmonella serotype Typhimurium, 2.0% for Yersinia enterocolitica, and 10.4% for Shigella sonnei. The vast majority of the outbreaks had not previously been registered. The wide variation in the ability to cause household outbreaks among the different types of bacteria reflects differences in their epidemiology and most likely also mirrors their overall outbreak potential. Differences in the time occurring between infections of household members may also indicate differences in the importance of person-to-person transmission for the different types of bacteria. The fact that household outbreaks occur with a relatively high frequency may be utilized in future analyses of sources of infection, in particular of Campylobacter, for which more household outbreaks than expected were identified.