Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins
Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins
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DOI：
10.1021/bm049551y
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发表时间：
2005-01-01
影响因子：
6.2
通讯作者：
Wooley, KL
中科院分区：
文献类型：
--
作者：
Becker, ML;Liu, JQ;Wooley, KL
通过活性自由基聚合（LFRP）在固体载体上合成的杂化肽-合成两亲性嵌段共聚物已被用作具有生物可利用肽的纳米材料的前体。LFRP引发剂，偶联到树脂上的肽末端，通过氮氧介导的自由基聚合（NMRP）或原子转移自由基聚合（ATRP）促进均聚物和嵌段共聚物的生长。本文中，描述了抗微生物肽tritrpticin的通用固体支持合成、活性自由基聚合引发剂与负载肽的树脂的偶联以及各种单体的受控自由基聚合以产生两亲性二嵌段共聚物。组装成胶束的肽合成嵌段共聚物和它们的体外生物学特性的初步评估进行了详细说明。
Hybrid peptidic-synthetic amphiphilic block copolymers, synthesized by living free radical Polymerization (LFRP) on solid support, have been utilized as precursors for nanoscale materials possessing bio-available peptides. LFRP initiators, coupled to the peptide terminus upon the resin, facilitated the growth of homo-and block copolymers via nitroxide mediated radical polymerization (NMRP) or atom transfer radical polymerization (ATRP). Herein, the versatile solid-support synthesis of the antimicrobial peptide tritrpticin, coupling of living free radical polymerization initiators to the peptide-loaded resin, and the controlled radical polymerization of various monomers to yield amphiphilic diblock copolymers are described. Assembly of the peptidic-synthetic block copolymers into micelles and a preliminary assessment of their in vitro biological properties are detailed.