Isolation, structural determination, and antiviral activities of metabolites from vanitaracin A-producing Talaromyces sp.
Isolation, structural determination, and antiviral activities of metabolites from vanitaracin A-producing Talaromyces sp.
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DOI：
10.1038/s41429-022-00585-9
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发表时间：
2023-03
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影响因子：
--
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Vanitaracin A 是一种抗乙型肝炎病毒聚酮化合物，之前已从 Talaromyces sp. 中分离出来。在本研究中，我们在不同条件下从产 Vanitaracin A 的真菌中获得的培养液中寻找新的化合物。分离出三种新化合物（vanitaracin C、vanitaraphilone A 和 2-羟基-4-（羟甲基）-6-甲基苯甲醛），并使用光谱方法（1D/2D NMR 和 MS）确定了它们的结构。此外，还通过测量 Vanitaracin A 对狂犬病病毒、博尔纳病病毒 1 和牛白血病病毒的抗病毒活性来检查其抗病毒谱。该化合物对牛白血病病毒表现出抗病毒活性，牛白血病病毒是地方性牛白血病的病原体。还评估了从产生 vanitaracin A 的真菌中分离出的其他化合物的抗牛白血病病毒作用，即 vanitaracins B 和 C、vanitaraphilone A 和 2-羟基-4-(羟甲基)-6-甲基苯甲醛。 Vanitaracin B、vanitaraphilone A 和 2-羟基-4-(羟甲基)-6-甲基苯甲醛也被发现具有抗牛白血病病毒的活性。这些发现揭示了vanitaracin支架的广谱抗病毒活性，并为开发抗牛白血病病毒药物提供了几种候选药物。
Vanitaracin A, an anti-hepatitis B virus polyketide, has been previously isolated from Talaromyces sp. In the present study, we searched for novel compounds in the culture broth obtained from a vanitaracin A-producing fungus under various conditions. Three novel compounds (vanitaracin C, vanitaraphilone A, and 2-hydroxy-4-(hydroxymethyl)-6-methylbenzaldehyde) were isolated, and their structures were determined using spectroscopic methods (1D/2D NMR and MS). In addition, the antiviral spectrum of vanitaracin A was examined by measuring its antiviral activities against rabies virus, Borna disease virus 1, and bovine leukemia virus. This compound exhibited antiviral activity against bovine leukemia virus, which is the causative agent of enzootic bovine leukosis. The anti-bovine leukemia virus effects of other compounds isolated from the vanitaracin A-producing fungus, namely, vanitaracins B and C, vanitaraphilone A, and 2-hydroxy-4-(hydroxymethyl)-6-methylbenzaldehyde, were also evaluated. Vanitaracin B, vanitaraphilone A and 2-hydroxy-4-(hydroxymethyl)-6-methylbenzaldehyde were also found to exhibit activity against bovine leukemia virus. These findings reveal the broad-spectrum antiviral activity of the vanitaracin scaffold and suggest several candidates for the development of anti-bovine leukemia virus drugs.
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3.8
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伊维菌素是进口蛋白α/β介导的核进口的特异性抑制剂，能够抑制HIV-1和登革热病毒的复制。
DOI：
10.1042/bj20120150
发表时间：
2012-05-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Wagstaff KM;Sivakumaran H;Heaton SM;Harrich D;Jans DA
通讯作者：
Jans DA