Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia
Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia
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脑灌注不足、轻度认知障碍和痴呆症的风险因素
DOI：
10.1016/s0197-4580(00)00136-6
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发表时间：
2000-03-01
影响因子：
4.2
通讯作者：
Haque, A
中科院分区：
文献类型：
--
作者：
Meyer, JS;Rauch, G;Haque, A
在神经学和认知正常的老年志愿者中，加速轻度认知功能下降和痴呆的假定危险因素与重复测量脑萎缩、CT、密度测量、灌流和认知测试相关。共有224名认知下降风险增加的标准受试者进入了这项研究。平均入院年龄为59.5+/-15.8岁。平均随访时间为5.8+/-3.3年。在随访中，22人出现轻度认知障碍(41人CCSE大于或等于-3)，19人痴呆-8人血管型(VAD)，11人阿尔茨海默病(DAT)-183人认知功能保持不变。用Xe-CT测量脑萎缩、组织密度和脑血流灌注。60岁以后，脑萎缩、脑室扩大、脊髓灰质炎和脑白质疏松症随着血流灌注的减少呈几何级数增加。加速血流灌注下降、脑萎缩、脊髓灰质炎和脑白质疏松的危险因素有：短暂性脑缺血发作(TIA)、高血压、吸烟、高脂血症和男性。在71.5+/-11.9岁时，轻度认知障碍开始因TIA、高血压和心脏病而加速。脑白质疏松在认知功能衰退之前就开始了。TIA、高血压和高脂血症与VAD相关。过度的皮质血流灌注减少，灰质和白质密度降低，以及大脑萎缩与认知能力下降有关。(C)2000 Elsevier Science Inc.保留所有权利。
Putative risk factors accelerating mild cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT, densitometry, perfusions, and cognitive testing among neurologically and cognitively normative aging volunteers. A total of 224 normative subjects at increased risk for cognitive decline were admitted to the study. Mean entry age was 59.5 +/- 15.8 years. Mean follow-up is 5.8 +/- 3.3 years. At follow-up, 22 developed mild cognitive impairment (41 CCSE greater than or equal to -3), 19 became demented-8 with Vascular type (VAD), 11 with Alzheimer's type (DAT)-and 183 remain cognitively unchanged. Cerebral atrophy, tissue densities, and perfusions were measured by Xe-CT. After age 60, cerebral atrophy, ventricular enlargement, and polio- and leuko-araiosis geometrically increased as perfusions declined. Risk factors accelerating perfusional decline, cerebral atrophy, polio-araiosis, and leuko-araiosis were: transient ischemic attacks (TIAs), hypertension, smoking, hyperlipidemia, and male gender. At age 71.5 +/- 11.9, mild cognitive impairment began accelerated by TIAs, hypertension and heart disease. Leuko-araiosis began before cognitive decline. TIAs, hypertension, and hyperlipidemia correlated with VAD. Excessive cortical perfusional decrease, gray and white matter hypodensities, and cerebral atrophy correlate with cognitive decline. (C) 2000 Elsevier Science Inc. All rights reserved.