Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.
Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.
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DOI：
10.4049/jimmunol.1301949
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发表时间：
2014-04-01
期刊：
影响因子：
--
通讯作者：
Noelle RJ
中科院分区：
文献类型：
--
作者：
Guo Y;Lee YC;Brown C;Zhang W;Usherwood E;Noelle RJ
Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RARα is required for the expression of gut-homing receptors on CD8+ T cells and survival of CD8+ T cells in vitro. Furthermore, RARα is essential for survival of CD8+ T cells in vivo following Listeria monocytogenes infection. In contrast, RARβ deletion leads to modest deficiency in Ag-specific CD8+ T cell expansion during infection. The defective survival of RARα-deficient CD8+ T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8+ T cell immunity.
