Host nuclear factor-κB activation potentiates lung cancer metastasis
Host nuclear factor-κB activation potentiates lung cancer metastasis
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DOI：
10.1158/1541-7786.mcr-07-0309
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发表时间：
2008-03-01
影响因子：
5.2
通讯作者：
Fingleton, Barbara
中科院分区：
文献类型：
--
作者：
Stathopoulos, Georgios T.;Sherrill, Taylor P.;Fingleton, Barbara
流行病学和实验证据表明，炎症和癌症之间存在联系，尽管这种关系最近才开始阐明肺癌，最常见的致命人类肿瘤。核因子-kappa B（NF-kappa B）是一种控制肺部先天免疫反应的转录因子，被认为是癌细胞增殖和转移潜力的重要决定因素;然而，它在肺肿瘤发生中的作用尚不确定。在这里，我们专门研究了NF-κ B诱导的气道炎症在肺癌转移中的作用，采用静脉注射刘易斯肺癌细胞到免疫活性的C57 BI/6小鼠模型。气道上皮细胞直接特异性NF-κ B活化诱导的肺部炎症增强肺腺癌转移此外，我们确定常驻肺巨噬细胞作为肺转移癌生长易感性的关键效应子。我们得出的结论是，宿主组织中的NF-κ B活性是肺转移发生的一个重要因素。
Epidemiologic and experimental evidence suggests that a link exists between inflammation and cancer, although this relationship has only recently begun to be elucidated for lung cancer, the most frequently fatal human tumor. Nuclear factor-kappa B (NF-kappa B), a transcription factor that controls innate immune responses in the lungs, has been implicated as an important determinant of cancer cell proliferative and metastatic potential; however, its role in lung tumorigenesis is uncertain. Here, we specifically examine the role of NF-kappa B-induced airway inflammation in lung cancer metastasis using a model of intravenous injection of Lewis lung carcinoma cells into immunocompetent C57BI/6 mice. Induction of lung inflammation by direct and specific NF-kappa B activation in airway epithelial cells potentiates lung adenocarcinoma metastasis. Moreover, we identify resident lung macrophages as crucial effectors of lung susceptibility to metastatic cancer growth. We conclude that NF-kappa B activity in host tissue is a significant factor in the development of lung metastasis.