The impact of diabetes mellitus on vitamin D metabolism in predialysis patients
The impact of diabetes mellitus on vitamin D metabolism in predialysis patients
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DOI：
10.1016/j.bone.2009.07.016
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发表时间：
2009-11-01
期刊：
影响因子：
4.1
通讯作者：
Rakugi, Hiromi
中科院分区：
文献类型：
--
作者：
Tanaka, Hirotaka;Hamano, Takayuki;Rakugi, Hiromi
虽然糖尿病（DM）会扰乱骨代谢，但其对慢性肾脏-矿物质和骨骼疾病（CKD-MBD）实验室异常的影响知之甚少。我们从大阪CKD患者维生素D研究（OVIDS-CKD）中提取了602例患者的数据，这是一项纳入透析前门诊患者的观察性研究。没有入组患者接受维生素D、双膦酸盐、雌激素或雷洛昔芬治疗。我们测量了1- 84 PTH、25-羟基维生素D （25D）、骨化三醇、成纤维细胞生长因子-23 （FGF-23）、钙（Ca）和磷酸盐(P)。由于有112名糖尿病患者（D组），我们提取了112名年龄、性别和egfr匹配的非糖尿病患者（N组）。我们比较各组间生化指标，然后对602名受试者进行多元回归分析，以证实所得结果。在CKD的各个阶段，D组的校正钙和校正磷均显著高于N组。D组25D随肾功能下降而降低，N组25D不变(相互作用P
Although diabetes mellitus (DM) disturbs bone metabolism, little is known concerning its effects on laboratory abnormalities in chronic kidney disease-mineral and bone disorders (CKD-MBD). We extracted data for 602 patients from the Osaka Vitamin D Study in patients with CKD (OVIDS-CKD), an observational study enrolling predialysis outpatients. No enrolled patients received vitamin D, bisphosphonate, estrogen or raloxifene. We measured 1- 84 PTH, 25-hydroxyvitamin D (25D), calcitriol, fibroblast growth factor-23 (FGF-23), calcium (Ca), and phosphate (P). Since there were 112 DM patients (group D), we extracted 112 age-, sex-, and eGFR-matched non-DM counterparts (group N). We compared biochemical markers between groups, and then performed multiple regression analyses for all 602 subjects to confirm the results obtained. Group D had significantly higher corrected Ca and P than group N throughout all stages of CKD. In group D, 25D decreased as renal function declined, while in group N it remained constant (interaction P