Graduated effects of high-altitude hypoxia and highland ancestry on birth size
Graduated effects of high-altitude hypoxia and highland ancestry on birth size
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DOI：
10.1038/pr.2013.150
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发表时间：
2013-12-01
影响因子：
3.6
通讯作者：
Giussani, Dino A.
中科院分区：
文献类型：
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作者：
Soria, Rudy;Julian, Colleen G.;Giussani, Dino A.
背景：我们提出了一组大约。玻利维亚 25,000 份目前成年男性和女性的出生记录。我们使用这个队列来检验这样的假设：高海拔会降低出生体重，而高原血统会针对这种影响提供分级保护。 方法：出生记录是从拉巴斯 (3,600 m) 和圣克鲁斯 (420 m) 的产科诊所和医院获得的。仅包括非吸烟母亲的单胎、健康足月（> 37 周）妊娠。安第斯、混血或欧洲血统是通过对父母姓氏进行验证分析来确定的。 结果：高海拔降低了出生时的体重（3,396 +/- 3 与 3,090 +/- 6 克）和身长（50.8 +/- 0 与 48.7 +/- 0 厘米）（P < 0.001）。高地血统部分免受高海拔对出生体重的影响（安第斯= 3,148 +/- 15 g；混血= 3,081 +/- 6 g；欧洲= 2,957 +/- 32 g；趋势P < 0.001），但对出生身长没有影响。高原妊娠对男婴和女婴出生体重的影响相似。结论：高海拔降低了出生体重，高原本土血统提供了分级保护。鉴于先前的研究将出生体重降低与心血管疾病风险增加联系起来，因此有必要进行进一步的研究来测试高原妊娠的成年人患心血管疾病的风险是否增加。
BACKGROUND: We present a cohort of ca. 25,000 birth records from Bolivia of men and women who are currently adults. We used this cohort to test the hypothesis that high altitude reduces birth weight and that highland ancestry confers graduated protection against this effect.METHODS: Birth records were obtained from obstetric clinics and hospitals in La Paz (3,600 m) and Santa Cruz (420 m). Only singleton, healthy term (> 37 wk) pregnancies of nonsmoking mothers were included. Andean, Mestizo, or European ancestry was determined by validated analysis of parental surnames.RESULTS: High altitude reduced body weight (3,396 +/- 3 vs. 3,090 +/- 6 g) and length (50.8 +/- 0 vs. 48.7 +/- 0 cm) at birth (P < 0.001). Highland ancestry partially protected against the effects of high altitude on birth weight (Andean = 3,148 +/- 15 g; Mestizo = 3,081 +/- 6 g; and European = 2,957 +/- 32 g; trend P < 0.001) but not on birth length. The effects of high-altitude pregnancy on birth size were similar for male and female babies.CONCLUSION: High altitude reduces birth weight and highland native ancestry confers graduated protection. Given previous studies linking reduced birth weight with increased risk of cardiovascular disease, further study is warranted to test whether adults from high-altitude pregnancy are at increased risk of developing cardiovascular disease.