Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys
Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys
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DOI：
10.1152/jn.01001.2007
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发表时间：
2008-02-01
影响因子：
2.5
通讯作者：
Yamane, Shigeru
中科院分区：
文献类型：
--
作者：
Murata, Yumi;Higo, Noriyuki;Yamane, Shigeru
为了研究损伤后训练对运动恢复的影响，我们比较了初级运动皮层（M1）损伤后接受高强度运动训练和未接受训练的猕猴的运动恢复情况。M1指区伊博滕酸病变导致手部功能受损，手指完全丧失运动能力。在损伤后进行强化训练（1小时/天，5天/周）的猴子，在损伤后训练1或2个月后，用于评估手灵巧性的行为指标恢复到与损伤前相同的水平。经过训练的猴子恢复了相对独立的手指运动，包括精确抓握（用手指和拇指对立来抓握一个小物体）。虽然未进行损伤后训练的猴子的手灵巧行为指标有一定程度的恢复，但直到M1损伤后几个月仍低于损伤前训练的猴子。未经训练的猴子经常使用交替的抓握策略，用受影响的手抓住一个小物体，用食指尖和拇指背夹住食物颗粒。这些结果表明，M1损伤后的恢复包括使用依赖过程和使用独立过程，并且在损伤后训练中强化使用受影响的手可以促进精确握力的恢复。
To investigate the effects of postlesion training on motor recovery, we compared the motor recovery of macaque monkeys that had received intensive motor training with those that received no training after a lesion of the primary motor cortex (M1). An ibotenic acid lesion in the M1 digit area resulted in impairment of hand function, with complete loss of digit movement. In the monkeys that had undergone intensive daily training (1 h/day, 5 days/wk) after the lesion, behavioral indexes used to evaluate manual dexterity recovered to the same level as in the prelesion period after 1 or 2 mo of postlesion training period. Relatively independent digit movements, including precision grip (prehension of a small object with finger-to-thumb opposition), were restored in the trained monkeys. Although the behavioral indexes of manual dexterity recovered to some extent in the monkeys without the postlesion training, they remained lower than those in the prelesion period until several months after M1 lesion. The untrained monkeys frequently used alternate grip strategies to grasp a small object with the affected hand, holding food pellets between the tip of the index finger and the dorsum of the thumb. These results suggest that the recovery after M1 lesion includes both use-dependent and use-independent processes and that the recovery of precision grip can be promoted by intensive use of the affected hand in postlesion training.