Cns germinoma with elevated serum human chorionic gonadotropin level: Clinical characteristics and treatment outcome
Cns germinoma with elevated serum human chorionic gonadotropin level: Clinical characteristics and treatment outcome
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DOI：
10.1016/j.ijrobp.2004.10.026
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发表时间：
2005-07-01
影响因子：
7
通讯作者：
Mimura, M
中科院分区：
文献类型：
--
作者：
Ogino, H;Shibamoto, Y;Mimura, M
目的：人绒毛膜促性腺激素（HCG）水平对中枢神经系统生殖细胞瘤预后的意义仍存在争议。本研究的目的是比较生殖细胞瘤患者的临床特点和预后与正常和高HCG滴度在serum.Methods和材料：我们进行了多机构的回顾性分析，103例中枢神经系统生殖细胞瘤的血清HCG和/或β-HCG水平已被测量治疗前1984年和2002年之间。所有患者均接受了单独放疗（n = 66）或联合化疗（n = 37），中位剂量为戈伊。在基底节区的病变中，产生HCG的肿瘤的比例高于其他部位的病变。肿瘤大小与HCG水平之间没有相关性，但大小与β-HCG之间似乎存在弱相关性。在HCG正常和高水平患者组中，5年和10年生存率分别为96%和94%（p = 0.99）。在HCG水平正常的患者中，5年和10年无复发生存率分别为87%和82%，在HCG水平高的患者中均为87%（p = 0.74）。此外，没有其他患者，肿瘤，或治疗相关因素似乎影响patients.Conclusion的预后：血清HCG水平似乎不影响患者的预后时，用足够剂量的放射治疗。肿瘤大小、部位与HCG水平的关系有待进一步研究。(c)2005年爱思唯尔公司
Purpose: The prognostic significance of human chorionic gonadotropin (HCG) level in central nervous system germinoma remains controversial. The purpose of this study was to compare clinical characteristics and prognosis of germinoma patients with normal and high HCG titers in the serum.Methods and Materials: We undertook a multi-institutional retrospective analysis of 103 patients with central nervous system germinoma whose serum HCG and/or beta-HCG level had been measured before treatment between 1984 and 2002. All patients had been treated with radiation therapy either alone (n = 66) or in combination with chemotherapy (n = 37) with a median dose of 47.8 Gy.Results: HCG and/or beta-HCG level in the serum was high in 39% of all patients. The proportion of HCG-producing tumors was higher in the lesions at the basal ganglia than in the lesions at the other sites. No correlation was found between tumor size and HCG level, but there seemed to be a weak correlation between size and beta-HCG. The 5- and 10-year survival rates were 96% and 94%, respectively, in both patient groups with normal and high HCG (p = 0.99). The 5- and 10-year relapse-free survival rates were 87 % and 82 %, respectively, in patients with normal HCG level and were both 87% in patients with high HCG (p = 0.74). Also, no other patient-, tumor-, or treatment-related factors seemed to influence the prognosis of the patients.Conclusion: Serum HCG level does not seem to influence patient prognosis when treated with sufficient doses of radiation. Relationship between tumor size and site and HCG level should be investigated further. (c) 2005 Elsevier Inc.