Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals
Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals
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DOI：
10.1109/biocas49922.2021.9644940
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
Kenji Sugie;K. Sasagawa;Yasumi Ohta;H. Takehara;M. Haruta;H. Tashiro;J. Ohta
中科院分区：
文献类型：
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作者：
Kenji Sugie;K. Sasagawa;Yasumi Ohta;H. Takehara;M. Haruta;H. Tashiro;J. Ohta
在这项工作中，我们开发了一种用于同时光学观察和电生理记录的植入式设备。原型图像传感器采用 0.35 µm 标准互补金属氧化物半导体工艺设计，并使用该图像传感器对小鼠脑切片进行绿色荧光蛋白荧光成像。此外，集成在同一芯片上的神经放大器用于放大微弱的神经信号，在40 mHz-3 kHz下获得了39 dB的中带增益，输入参考噪声为4.9 µVrms。使用软件滤波器减少了神经放大器输出中观察到的图像传感器时钟信号的串扰。
In this work, we developed an implantable device for simultaneous optical observation and electrophysiological recording. The prototype image sensor was designed using a 0.35-µm standard complementary metal-oxide-semiconductor process, and green fluorescent protein fluorescence imaging of mouse brain slices was performed using the image sensor. In addition, a neural amplifier integrated on the same chip to amplify the weak neural signals obtained a midband gain of 39 dB at 40 mHz-3 kHz, and the input-referred noise was 4.9 µVrms. Crosstalk of the image sensor clock signal observed in the neural amplifier output was reduced using a software filter.