Ten year follow up of pulmonary function in patients with primary Sjogren's syndrome
Ten year follow up of pulmonary function in patients with primary Sjogren's syndrome
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DOI：
10.1136/ard.59.9.709
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发表时间：
2000-09-01
影响因子：
27.4
通讯作者：
Griffiths, ID
中科院分区：
文献类型：
--
作者：
Davidson, BKS;Kelly, CA;Griffiths, ID
目的：随访原发性干燥综合征（SS）患者的肺功能，并描述了对该队列进行中位持续时间为10年的随访的结果（年龄8-12岁）。30例符合Fox标准的明确或可能原发性SS的患者在诊断后6个月内和中位持续时间为4年和10年后进行评估，临床检查、胸片和肺功能研究（FEV 1、FVC、TLCO和KCO）.结果-在基线时，有症状的呼吸困难是常见的发现，30名患者中有13名报告，其中2名在普通胸片上有纤维化肺泡炎的证据。五名患者的一氧化碳转移因子（TLCO）超过两个标准化残差低于预测值。4年随访后，又有2例患者出现放射学纤维化改变，TLCO显著降低（p
Objectives-To follow up a previous report on the lung function of patients with primary Sjogren's syndrome (SS), and describe the findings having followed up this cohort for a median duration of 10 years (range 8-12 years).Methods-30 patients fulfilling Fox's criteria for definite or probable primary SS were assessed within six months of diagnosis and after a median duration of four and then 10 years by a clinical examination, chest radiograph, and lung function studies (FEV1, FVC, TLCO, and KCO).Results-At baseline, symptomatic dyspnoea was a common finding, reported by 13/30 patients, of whom two had evidence of fibrosing alveolitis on plain chest radiograph. Five patients had a carbon monoxide transfer factor (TLCO) more than two standardised residuals below the predicted value. After four years' follow up two further patients developed radiological fibrotic changes and there were significant reductions in TLCO (p