APOLIPOPROTEIN-E POLYMORPHISM AND ALZHEIMERS-DISEASE
APOLIPOPROTEIN-E POLYMORPHISM AND ALZHEIMERS-DISEASE
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DOI：
10.1016/0140-6736(93)91705-q
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发表时间：
1993-09-18
期刊：
影响因子：
168.9
通讯作者：
GAUTHIER, S
中科院分区：
文献类型：
--
作者：
POIRIER, J;DAVIGNON, J;GAUTHIER, S
载脂蛋白E （apoE）与阿尔茨海默病的神经原纤维缠结和老年斑中的β -淀粉样蛋白有关。它似乎也在脑内神经分化和神经退行性变后的脂质再分配中起重要作用。载脂蛋白e基因位于19号染色体上，位于先前与晚发性家族性阿尔茨海默病（AD）相关的基因组区域内。我们研究了91例散发性AD患者和74例对照患者的apoE表型表达和相应的等位基因频率（epsilon2、epsilon3、epsilon4）。epsilon4与散发性AD之间存在显著相关性（AD患者的epsilon4频率为0.380，对照组为0.122）
Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. It also appears to play an important part in the redistribution of lipids that follows deafferentation and neurodegeneration in the brain. The gene for apoE is on chromosome 19, within the genomic region previously associated with late-onset familial Alzheimer's disease (AD).We have studied apoE phenotype expression and the corresponding allele frequencies (epsilon2, epsilon3, epsilon4) in 91 patients with sporadic AD and 74 controls. There was a significant association between epsilon4 and sporadic AD (epsilon4 frequency 0.380 in AD and 0.122 in controls, p