ULTRASTRUCTURAL-STUDY OF TENSION AND PRESSURE ZONES IN A RABBIT FLEXOR TENDON
ULTRASTRUCTURAL-STUDY OF TENSION AND PRESSURE ZONES IN A RABBIT FLEXOR TENDON
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DOI：
10.1002/aja.1001570109
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
FLINT, MH
中科院分区：
文献类型：
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作者：
MERRILEES, MJ;FLINT, MH
兔后肢的指深屈肌腱在其大部分长度上都受到张力的影响，但是，在与跟骨和距骨接触的局部区域内，它受到额外的压缩力。与张力区相比，这个承压区具有纤维软骨样组织和高浓度的糖胺聚糖（GAG）。张力区和压力区细胞、胶原和基质的超微结构特征明显不同，在张力区和压力区之间的交界区有全谱的过渡性特征。显然，各个区域的细胞对物理负荷的变化是敏感和敏感的。在张力区，细长的细胞具有广泛的细胞质法兰，可以与相邻细胞的法兰接触，并且呈扇形的细胞表面与相邻的带正电且紧密堆积的长周期（63 nm）和不同直径的胶原原纤维紧密贴合。在压力区，圆形和集群的纤维软骨样细胞，以直径11 nm的微丝密集排列和大量脂滴为特征，被松散堆积的短周期（53 nm）、主要是小直径的胶原原纤维和富含GAG的广泛基质所包围。显然，这些细胞外成分的区域形态变化是细胞合成活动变化的间接原因，而细胞合成活动的变化是对物理环境变化的反应。
The flexor digitorum profundus tendon of the rabbit hind limb is subject to tensional forces throughout most of its length, but, within a localized area which is in contact with the calcaneum and talus, it is subjected to additional compressive forces. This pressure-bearing area, in marked contrast to the tensional areas, has a fibrocartilage-like organization and a high concentration of glycosaminoglycans (GAG). Ultrastructural features of the cells, collagen and matrix in the tension and pressure zones are markedly different, with a full spectrum of transitional characteristics in the junctional region between the 2 zones. Apparently the cells in the various regions are sensitive and responsive to changes in physical load. In the tensional zone, elongated cells have extensive cytoplasmic flanges, which may contact flanges of neighboring cells, and a scalloped cell surface that intimately conforms to the adjacent positively charged and tightly packed collagen fibrils of long periodicity (63 nm) and varying diameters. In the pressure zone, round and clustered fibrocartilage-like cells, characterized by dense arrays of 11 nm diameter microfilaments and numerous lipid droplets, are surrounded by loosely packed collagen fibrils of short periodicity (53 nm) and predominantly small diameters and an extensive matrix rich in GAG. Apparently these regional morphological variations in the extracellular components result from, and are indirectly the cause of, changes in the cellular synthetic activities which occur in response to changes in physical environment.