Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.

Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
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生长抑素激活蛋白酪氨酸磷酸酶并灭活 Raf-1。

DOI:
10.1042/bj3140401
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发表时间:
1996
期刊:
The Biochemical journal
影响因子:
--
通讯作者:
Sturgill,TW
Sturgill,TW
中科院分区:
--
文献类型:
--
作者:
Reardon,DB;Wood,SL;Brautigan,DL;Bell,GI;Dent,P;Sturgill,TW

文献摘要

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Human somatostatin receptor 3 ('hsstr3') was transiently expressed in NIH 3T3 cells stably transformed with Ha-Ras (G12V). Somatostatin activated a protein tyrosine phosphatase and inactivated the constitutively active, membrane-associated form of the Raf-1 serine kinase present in these cells in vivo and in vitro.