Myocardial contrast echocardiography for predicting functional recovery after acute myocardial infarction
Myocardial contrast echocardiography for predicting functional recovery after acute myocardial infarction
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心肌造影超声心动图预测急性心肌梗死后功能恢复
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
G. Baumann
中科院分区：
文献类型：
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作者：
A. Borges;W. Richter;C. Witzel;M. Witzel;A. Grohmann;R. Reibis;W. Rutsch;I. Küchler;D. Munz;G. Baumann
心肌造影超声心动图（MCE）是一种有前途的检测微血管完整性的诊断工具。本研究的目的是探讨静脉 MCE、锝-99m Sestamibi 单光子发射计算机断层扫描 (SPECT) 和双嘧达莫-多巴酚丁胺 (DIDO) 负荷超声心动图在预测急性心肌梗死 (AMI) 患者冠状动脉血运重建后功能恢复方面的比较特异性和敏感性。方法：在一项前瞻性、观察性研究中，连续 17 名在 AMI 后不久接受初次经皮冠状动脉成形术 (PTCA) 加支架植入术成功治疗的患者在 2 天内接受 DIDO（双嘧达莫 0.28 mg/kg，持续 4 分钟加多巴酚丁胺，最高 10 mcg/kg/min）、MCE（10 ml 4 g、400 mg/ml Levovist® 静脉注射；二次谐波功率成像）检查。 PTCA 后 12-24 小时和 48-72 小时内静息灌注 SPECT。 6个月随访后区域收缩功能的功能恢复是评估活力的金标准。结果：SPECT 和 MCE 之间的一致率为 69%，对于组合 DIDO，SPECT 与应力回波阳性反应之间的一致率为 76%。 MCE 在活力鉴定方面表现出比 SPECT (77%) 和单独组合 DIDO (79%) 更高的灵敏度 (96%)。与 SPECT (93%) 和 DIDO (87%) 相比，MCE (58%) 的活力识别特异性较低。结论：DIDO 超声心动图期间的室壁运动反应有助于预测 AMI 患者血运重建后局部和整体心室功能的恢复情况。静脉 MCE 和 DIDO 相结合在诊断心肌顿抑方面比单独使用 Tc-99m-MIBI SPECT 更准确。
Myocardial contrast echocardiography (MCE) is a promising diagnostic tool for detecting microvascular integrity. The aim of the study was to investigate the comparative specificity and sensitivity of intravenous MCE, technetium-99m Sestamibi single-photon emission computed tomography (SPECT) and dipyridamole–dobutamine (DIDO) stress echocardiography for predicting functional recovery after coronary revascularization in patients with acute myocardial infarction (AMI). Methods: In a prospective, observational study, 17 consecutive patients short after AMI who received successful treatment with primary percutaneous coronary angioplasty (PTCA) plus stent-implantation were examined with DIDO (dipyridamole with 0.28 mg/kg over 4 min plus dobutamine up to 10 mcg/kg/min), MCE (10 ml 4 g, 400 mg/ml Levovist® intravenously; second harmonic power imaging) within 12–24 h and resting perfusion SPECT within 48–72 h after PTCA. Functional recovery of regional contractile function after 6-month follow-up was the gold standard to assess viability. Results: The rate of agreement between SPECT and MCE was 69% and between SPECT and a positive response to stress echo was 76% for combined DIDO. MCE showed a higher sensitivity (96%) in the identification of viability than SPECT (77%) and combined DIDO alone (79%). Specificity was lower for viability recognition with MCE (58%) compared with SPECT (93%) and DIDO (87%). Conclusions: The wall motion response during DIDO echocardiography is useful in the prediction of recovery of regional and global ventricular function after revascularization in patients after AMI. Combined intravenous MCE and DIDO is more accurate in the diagnosis of stunned myocardium than Tc-99m-MIBI SPECT alone.
心肌造影超声心动图：15 年的研究和开发。
影响因子：
37.8
作者：
Kaul,S
通讯作者：
Kaul,S
使用主动脉根部注射微泡结合谐波成像进行急性心肌梗死的心肌造影超声心动图：在心导管插入术实验室中的潜在应用。
影响因子：
24
作者：
Firschke,C;Lindner,JR;Goodman,NC;Skyba,DM;Wei,K;Kaul,S
通讯作者：
Kaul,S