Human group A rotavirus P[8] Hun9-like and rare OP354-like strains are circulating among diarrhoeic children in Eastern India
Human group A rotavirus P[8] Hun9-like and rare OP354-like strains are circulating among diarrhoeic children in Eastern India
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DOI：
10.1007/s00705-008-0187-6
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发表时间：
2008-09
影响因子：
2.7
通讯作者：
S. Samajdar;S. Ghosh;D. Dutta;M. Chawla-Sarkar;N. Kobayashi;T. Naik
中科院分区：
文献类型：
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作者：
S. Samajdar;S. Ghosh;D. Dutta;M. Chawla-Sarkar;N. Kobayashi;T. Naik
2004-2006年，在东印度腹泻儿童中，A组轮状病毒P[8]毒株是主要的VP4基因型别(43.2%，n=1317)。对其中16株毒株与其他P[8]毒株的VP8*氨基酸序列进行了系统发育分析，发现有4种不同的谱系。来自印度东部的P[8]毒株聚集在罕见的类OP354和类Hun9的谱系中，表明存在差异的P[8]毒株共同流行。虽然尚不清楚观察到的遗传多样性是否可能在一定程度上影响疫苗的效力，但本研究强调了进一步努力解决印度次大陆各地关于P[8]菌株多样性的信息非常缺乏的问题。
During 2004–2006, group A rotavirus P[8] strains were the major VP4 genotype (43.2%,n= 317) among diarrhoeic children in Eastern India. Phylogenetic analysis of VP8* amino acid sequences of 16 of these strains with other P[8] strains revealed four distinct lineages. P[8] strains from Eastern India clustered within rare OP354-like and Hun9-like lineages, pointing towards co-prevalence of divergent P[8] strains. Although it is unclear whether the observed genetic diversity might affect to some extent the efficacy of vaccines, the present study emphasized further efforts to address the much lacking information on diversity of P[8] strains across the Indian subcontinent.