Converging functional and anatomical evidence for novel brainstem respiratory compartments in the rat.
Converging functional and anatomical evidence for novel brainstem respiratory compartments in the rat.
复制标题
大鼠新型脑干呼吸区室的功能和解剖学证据的融合。
DOI：
10.1007/0-387-27023-x_16
复制
发表时间：
2004
影响因子：
--
通讯作者：
Topgi,Anupama
中科院分区：
文献类型：
--
作者：
McCrimmon,DonaldR;Alheid,GeorgeF;Jiang,Minchun;Calandriello,Tara;Topgi,Anupama
控制呼吸运动神经元的中枢神经系统回路通常分为背侧延髓呼吸组-与孤束核的部分相关，腹外侧延髓呼吸组-主要位于疑核运动神经元的腹侧，以及脑桥呼吸组-与臂旁核复合体的部分相关。当通过逆行标记来自延髓腹外侧内注射的神经元来可视化时（图1A），脑桥和延髓中的脑桥相关神经元的标记聚集体似乎形成实际上连续的细胞柱。这些集中在从中脑尾部延伸到脑桥和延髓的侧脑干区域1 -4。这种标记模式突出了呼吸神经元的吻尾柱状组织，其整合了整个菱脑范围内的呼吸控制。第二个组织主题由该列内呼吸神经元的吻尾分割为功能区室表示（图1B）。
Central nervous system circuits controlling respiratory motoneurons have usually been divided into a dorsal medullary respiratory group—associated with portions of the nucleus of the solitary tract, a ventrolateral medullary respiratory group—mostly ventral to the motoneurons of nucleus ambiguus, and a pontine respiratory group—associated with portions of the parabrachial nuclear complex. When visualized via retrograde labeling of neurons from injections within the ventrolateral medulla (Fig. 1 A), the labeled aggregates of respiratory-related neurons in the pons and medulla appear to form a practically continuous column of cells. These are concentrated in lateral brainstem areas stretching from the caudal mesencephalon, through the pons and medulla1—4. This pattern of labeling highlights the rostrocaudal columnar organization of respiratory neurons that integrates respiratory control across the entire extent of the rhombencephalon. A second organizational theme is represented by a rostrocaudal segmentation of respiratory neurons within this column into functional compartments (Fig. 1B).