Principles of memory CD8 T-cells generation in relation to protective immunity.
Principles of memory CD8 T-cells generation in relation to protective immunity.
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DOI：
10.1007/978-1-4419-6451-9_9
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发表时间：
2010
影响因子：
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通讯作者：
M. Zanetti;P. Castiglioni;E. Ingulli
中科院分区：
文献类型：
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作者：
M. Zanetti;P. Castiglioni;E. Ingulli
记忆性T细胞应答在理解宿主对病原体和癌细胞的免疫应答以及开始建立对疾病的保护的相关性方面是至关重要的。在这篇综述中，我们讨论了我们自己的数据，在目前的知识的一般情况下，勾勒出暂定的工作原理，通过接种疫苗诱导保护性T细胞反应。我们提请注意与抗原的初始接触的定量和定性方面，以及其后导致记忆T细胞产生的事件的动力学。我们的论点是基于目前记忆T细胞分为两个谱系：效应记忆T细胞（TEM）和中央记忆T细胞（TCM）。我们的初步结论是，保护性T细胞反应与中央记忆表型的T细胞正相关。在提出一组通过疫苗接种使保护性记忆T细胞成为可能的工作原理时，我们分别在免疫学经验不足和免疫学经验丰富的个体的背景下解决了疫苗接种。最后，我们提请注意系统和局部免疫之间的相互作用，作为决定记忆T细胞反应在保护个体方面的成功的重要因素。我们认为，考虑记忆诱导和维持的免疫动力学，记忆谱系分化及其与保护的关系可能有助于设计控制病原体和癌症引起的疾病的策略。
Memory T-cell responses are of vital importance in understanding the host’s immune response against pathogens and cancer cells and to begin establishing the correlation of protection against disease. In this review, we discuss our own data in the general context of current knowledge to sketch tentative working principles for the induction of protective T-cell responses by vaccination. We draw attention to quantitative and qualitative aspects of the initial contact with antigen, as well as to the kinetics of events leading to the generation of memory T cells thereafter. Our arguments are based on the current distinction of memory T cells into two lineages: effector memory T cells (TEM) and central memory T cells (TCM). Our provisional conclusion is that protective T-cell responses correlate positively with the T cells of the central memory phenotype. In proposing a set of working principles to enable protective memory T cells by vaccination we address vaccination both in the context of the immunologically-inexperienced and immunologically-experienced individual, respectively. Finally, we draw attention to the interplay between systemic and local immunity as important factors in determining the success of memory T-cell responses in protecting the individual. We believe that considerations on the immunodynamics of memory induction and maintenance, memory lineage differentiation and their relation to protection may help design strategies to control disease caused by pathogens and cancer.