Notch signaling
Notch signaling
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陷波信号
DOI：
10.1111/dgd.12642
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kenji Matsuno
中科院分区：
文献类型：
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作者：
Kenji Matsuno
万事皆有开始。追溯历史，大约在世纪前，托马斯亨特摩根发现了一个突变，被命名为“Notch”，以果蝇的翅膀切口表型命名。研究了与Notch突变胚胎相关的表型，其揭示了突变体中的神经增生，现在称为神经源性表型。自从Notch基因被发现以来，Notch基因就被认为是一个重要的发育基因。利用模式生物，如果蝇和秀丽隐杆线虫，通过遗传分析揭示了Notch信号传导的遗传途径。然后，在发现Notch途径在人类中非常保守后，Notch信号传导的研究蓬勃发展。这些发现开辟了新的途径，导致建立其医学重要性，如在癌症生物学，免疫学，血管生成和干细胞生物学。Notch生物学的这一繁荣阶段似乎还在继续。在这种情况下，全面的审查，涵盖了在Notch途径的研究领域的活跃在这个特殊的问题。现在，我们应该进一步开发操纵Notch信号的方法，以治疗与Notch通路异常相关的疾病。
Everything has a beginning. Tracing back history, about one century ago, Thomas Hunt Morgan found a mutation that was designated as “Notch”, named after the wing notch phenotype in Drosophila. Phenotypes associated with Notch mutant embryos were investigated, which revealed neural hyperplasia in the mutant, now known as neurogenic phenotype. Ever since such a pivotal finding was made, Notch gene had been considered as an important developmental gene. Using model organisms, such as Drosophila and Caenorhabditis elegans, the genetic pathway of Notch signaling was uncovered by virtue of genetic analyses. Then, the study of Notch signaling blossomed after the discovery that the Notch pathway is extremely well conserved in humans. Such findings opened new avenues leading to the establishment of its medical importance, such as in cancer biology, immunology, angiogenesis, and stem cell biology. This blooming phase of Notch biology seems to continue. Under such conditions, comprehensive reviews covering the active fields of research in the Notch pathway are presented in this special issue. Now, we should go further to develop ways for manipulating Notch signaling to cure diseases associated with abnormalities in the Notch pathway.