A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring.
A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring.
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DOI：
10.3762/bjoc.12.236
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发表时间：
2016
影响因子：
2.7
通讯作者：
Andraos J
中科院分区：
文献类型：
--
作者：
Andraos J
提出了一种新的方法来发展新的合成策略，用于构建有机分子中发现的单环。该方法是基于整数分割的化学结构的可视化应用。解决了两个问题：（1）确定由2-、3-和4-分量耦合构造给定环的可能方式的总数;（2）系统地列举这些可能性。使用环己酮，吡唑，和Biginelli加合物作为目标环系统的方法的结果进行说明，以期发现新的和更绿色的策略，其建设使用多组分反应。该方法的应用也扩展到许多天然产物和药物中发现的各种杂环。
A new way of developing novel synthesis strategies for the construction of monocyclic rings found in organic molecules is presented. The method is based on the visual application of integer partitioning to chemical structures. Two problems are addressed: (1) the determination of the total number of possible ways to construct a given ring by 2-, 3-, and 4-component couplings; and (2) the systematic enumeration of those possibilities. The results of the method are illustrated using cyclohexanone, pyrazole, and the Biginelli adduct as target ring systems with a view to discover new and greener strategies for their construction using multicomponent reactions. The application of the method is also extended to various heterocycles found in many natural products and pharmaceuticals.