The association between early-life famine exposure and adulthood obesity on the risk of dyslipidemia
The association between early-life famine exposure and adulthood obesity on the risk of dyslipidemia
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早期饥荒暴露与成年期肥胖与血脂异常风险的关系
DOI：
10.1016/j.numecd.2022.06.005
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Jieli Lu
中科院分区：
文献类型：
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作者：
Chunyan Hu;Rui Du;Lin Lin;Ruizhi Zheng;Hongyan Qi;Yuanyue Zhu;Ran Wei;Xueyan Wu;Yi Zhang;Mian Li;Tiange Wang;Zhiyun Zhao;Min Xu;Yu Xu;Yufang Bi;Guang Ning;Weiqing Wang;Yuhong Chen;Jieli Lu
饥饿暴露和成年肥胖对血脂异常风险的联合影响尚不清楚。因此，我们的目的是探讨饥饿暴露和成年肥胖对血脂异常风险的联合作用，以及成年全身或腹部肥胖对饥饿暴露和血脂异常之间的关联的潜在影响。我们在8880名40岁或以上的受试者中进行了一项基于社区的队列研究。根据出生日期将参与者分为未暴露、胎儿暴露、儿童期暴露和婴儿期暴露。根据体重指数（BMI：超重≥24.0 kg/m2，肥胖≥28.0 kg/m2）和腰臀比（WHR，男/女：中度≥0.90/0.85，高度≥0.95/0.90）定义全身性肥胖和腹型肥胖。使用国家胆固醇教育计划成人治疗组III标准定义血脂异常。在整个研究中，与未暴露的参与者相比，胎儿暴露个体的血脂异常风险显著增加（OR：1.24，95%CI：1.03-1.50）。在女性中观察到与饥饿暴露相关的血脂异常风险显著增加[胎儿和儿童期暴露组的OR（95%CI）分别为1.36（1.05-1.76）和1.70（1.22-2.37），但男性中未观察到。此外，全身性肥胖和中心性肥胖与饥饿暴露对血脂异常的风险具有显著的乘法交互作用（交互作用P分别= 0.0001和< 0.0001）。饥饿暴露和腰臀比对女性血脂异常的风险存在显著的相加交互作用，交互作用导致的相对超额风险（RERI）和95%CI为0.43（0.10-0.76）。
The joint effect of famine exposure and adulthood obesity on risk of dyslipidemia remains unclear. Thus, we aim to explore the joint effect of famine exposure and adulthood obesity on the risk of dyslipidemia, and the potential effect of adult general or abdominal obesity on the association between famine exposure and dyslipidemia.We conducted a community-based cohort study in 8880 subjects aged 40 years or older. Participants were divided into nonexposed, fetal-exposed, childhood-exposed, adolescent-exposed according to birth date. General obesity and abdominal obesity were defined according to body mass index (BMI: overweight≥24.0 kg/m2, obesity≥28.0 kg/m2) and waist-to-hip ratio (WHR, men/women: moderate≥0.90/0.85, high≥0.95/0.90). Dyslipidemia was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Compared with nonexposed participants, fetal-exposed individuals had significantly increased risk of dyslipidemia (OR:1.24, 95%CI: 1.03-1.50) in the whole study. Significant increased risk of dyslipidemia related to famine exposure was observed in women [ORs (95%CIs) were 1.36 (1.05-1.76) and 1.70 (1.22-2.37) for the fetal and childhood-exposed group, respectively but not in men. Moreover, both general and central obesity had significant multiplicative interactions with famine exposure for the risk of dyslipidemia (P for interaction = 0.0001 and < 0.0001, respectively). Significant additive interaction was found between famine exposure and WHR on risk of dyslipidemia in women, with the relative excess risk due to interaction (RERI) and 95% CI of 0.43 (0.10-0.76).Coexistence of early-life undernutrition and adulthood obesity was associated with a higher risk of dyslipidemia in later life.