Histocompatible healing of periodontal defects after application of an injectable calcium phosphate bone cement. A preliminary study in dogs
Histocompatible healing of periodontal defects after application of an injectable calcium phosphate bone cement. A preliminary study in dogs
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DOI：
10.1902/jop.2002.73.9.1043
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发表时间：
2002-09-01
影响因子：
4.3
通讯作者：
Ishikawa, I
中科院分区：
文献类型：
--
作者：
Shirakata, Y;Oda, S;Ishikawa, I
背景：一种新型的可注射、快凝磷酸钙骨水泥（CPC）目前用于骨折的骨科治疗。本研究评价了应用这种水泥愈合牙周defens.Methods的可能性：开窗和3壁牙周缺损手术创建的双侧第一磨牙和犬齿在5只比格犬。CPC应用于一侧下颌骨缺损。对侧未处理的缺损作为对照。CPC应用于上颌骨的所有缺损。手术后12周，处死动物，制备脱钙和未脱钙标本。牙周组织愈合进行了评估，组织学和histometrically在光学microscope.Results：愈合牙周组织的骨和牙骨质形成方面的CPC应用的网站一致观察。CPC部分被新骨替代。残留的CPC似乎从裸露的根面脱离。CPC与牙根面之间可见新生牙骨质和牙周韧带样组织。在CPC应用部位未观察到不良反应。在histometric analysis.Conclusions的实验或对照网站没有统计学上的显着差异：虽然有两个治疗组之间没有统计学上的显着差异，组织学观察表明，CPC似乎作为骨形成的支架，并提供组织相容性愈合的牙周组织在这项研究中。这种骨水泥可能适用于牙周治疗;然而，需要进一步的研究。
Background: A novel injectable, fast setting calcium phosphate cement (CPC) is currently used in orthopedic therapy for bone fractures. This study evaluated the possibility of applying this cement to healing periodontal defects.Methods: Fenestrations and 3-walled periodontal defects were surgically created on bilateral first molars and canines in 5 beagle dogs. CPC was applied to the defects on one side of the mandible. Untreated defects on the contralateral side served as controls. CPC was applied to all defects in the maxilla. Twelve weeks after surgery, the animals were sacrificed and decalcified and undecalcified specimens were prepared. Periodontal tissue healing was evaluated histologically and histometrically under a light microscope.Results: Healing of periodontal tissues in terms of bone and cementum formation was consistently observed in the CPC-applied sites. CPC was partly replaced by new bone. The residual CPC appeared detached from the denuded root surface. New cementum and periodontal ligament-like tissue were observed between the detached CPC and root surface. No unfavorable reaction was noted in the CPC-applied sites. No statistically significant difference was noted in the experimental or control sites under histometric analysis.Conclusions: Although there were no statistically significant differences between the 2 treatment groups, histological observation indicated that CPC seemed to act as a scaffold for bone formation and provided histocompatible healing of periodontal tissues in this study. This cement might be applicable to periodontal therapy; however, further investigations are required.