Molecular pathways controlling heart development
Molecular pathways controlling heart development
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DOI：
10.1126/science.272.5262.671
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发表时间：
1996-05-03
期刊：
影响因子：
56.9
通讯作者：
Srivastava, D
中科院分区：
文献类型：
--
作者：
Olson, EN;Srivastava, D
心脏的形成需要来自多个胚胎来源的细胞之间复杂的相互作用。最近的研究已经开始揭示控制心脏形态发生的遗传途径。这些途径中的许多基因在巨大的系统发育距离上是保守的，这使得从苍蝇到哺乳动物的各种生物的心脏发育得以解剖。对心脏发育的研究也揭示了人类几种先天性心脏畸形背后的分子缺陷，并最终可能提供基因测试和干预的机会。
Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.