Analysis of site‐specific transgene integration following cotransduction with recombinant adeno‐associated virus and a rep encodingplasmid

Analysis of site‐specific transgene integration following cotransduction with recombinant adeno‐associated virus and a rep encodingplasmid
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DOI：
10.1002/jgm.324
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发表时间：
2003-02
期刊：
The Journal of Gene Medicine
影响因子：
--
通讯作者：
N. Huttner;A. Girod;S. Schnittger;C. Schoch;M. Hallek;H. Büning
N. Huttner;A. Girod;S. Schnittger;C. Schoch;M. Hallek;H. Büning
中科院分区：
其他
文献类型：
--
作者：
N. Huttner;A. Girod;S. Schnittger;C. Schoch;M. Hallek;H. Büning

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与其他载体系统相比，重组腺相关病毒（rAAV）在基因治疗应用方面具有许多优势。最有希望的特征之一是野生型（wt）AAV位点特异性整合到人19号染色体中的能力。然而，由于去除了复制编码序列，rAAV载体中失去了该特征。
Recombinant adeno‐associated virus (rAAV) has many advantages for gene therapeutic applications in comparison with other vector systems. One of the most promising features is the ability of wild‐type (wt) AAV to integrate site‐specifically into human chromosome 19. However, this feature is lost in rAAV vectors due to the removal of the rep‐coding sequences.