Studies toward the total synthesis of angelmicin B (hibarimicin B):: Synthesis of a model CD-D′ arylnaphthoquinone
Studies toward the total synthesis of angelmicin B (hibarimicin B):: Synthesis of a model CD-D′ arylnaphthoquinone
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DOI：
10.1021/ol048436x
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发表时间：
2004-10-14
期刊：
影响因子：
5.2
通讯作者：
Roush, WR
中科院分区：
文献类型：
--
作者：
Narayan, S;Roush, WR
(图表)描述了通过D'芳基硼酸15与CD溴萘醌21的Suzuki偶联合成对应于天使霉素B的CD-D'单元的芳基萘醌22。导致 22 的 Suzuki 交叉偶联的温和条件可能被证明对于 Angelmicin B 的两个高度功能化的半部分的最终后期偶联是有用的。
(GRAPHICS)A synthesis of arylnaphthoquinone 22 corresponding to the CD-D' unit of angelmicin B via the Suzuki coupling of the D' arylboronic acid 15 with the CD bromonaphthoquinone 21 is described. The mild conditions for the Suzuki cross-coupling leading to 22 may prove to be useful for the eventual late-stage coupling of the two highly functionalized halves of angelmicin B.